Symptoms and Grading

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Symptoms and grading of skin toxicities associated with multikinase inhibitor treatment

This section addresses symptoms and grading of skin toxicities associated with multikinase inhibitors. Only side effects affecting skin and their adnexes, hairs, nails, and oral complaints (stomatitis) are discussed.

This section, ‘Symptoms and grading’, comprises the following sub-sections:

• Terminology: the wording used on the website for the description and grading of skin toxicities
• Incidence: the frequency of new skin toxicities
• Types and grades of skin toxicities
  • Skin changes: type and grade of cutaneous changes
    • Papulopustular rash
    • Maculopapular rash
    • Hand-foot skin reaction
    • Dry Skin
    • Pruritus
  • Photosensitivity: type and grade of photosensitivity
  • Papilloma and squamous cell carcinoma: type and grade of papilloma and squamous cell carcinoma
  • Nail changes: type and grade of nail changes
  • Hair changes: type and grade of hair changes
  • Stomatitis: type and grade of stomatitis
• Differential diagnosis: Review of dermatologic changes unrelated to multikinase inhibitor treatment