Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Hasenclever-Index for Hodgkin's Disease

Predicting the outcome is important to avoid overtreating some patients with Hodgkin's disease, and to identify others in whom standard treatment is likely to fail. Seven factors with similar independent prognostic effects were selected. The prognostic score was then defined as the number of adverse prognostic factors present at diagnosis. The prognostic score was used to predict rates of freedom from progression of disease (panel A) and overall survival (panel B). The panel also presents freedom from progression of disease according to whether the prognostic score was 0-2, 3 or higher.

Definition

Factor

Log Hazard Ratio

p

Relative Risk

1. Serum albumin <40 g/l

0.40 ± 0.10

<0.001

1.49

2. Hemoglobin <105 g/l

0.30 ± 0.11

0.006

1.35

3. Male sex

0.30 ± 0.09

0.001

1.35

4. Stage 4 disease

0.23 ± 0.09

0.011

1.26

5. Age ≥ 45 years

0.33 ± 0.10

0.001

1.39

6. White blood cells ≥ 15 G/l

0.34 ± 0.11

0.001

1.41

7. Lymphocytes < 0.6 G/l or <8% of white blood cells

0.31 ± 0.10

0.002

1.38

Survival curves

Legends

Legend A & B

Use of the Prognostic Score to Predict Rates of Overall Survival and Freedom from Progression of Disease in 1618 Patients with Advanced Hodgkin's Disease. The number and percentage of patients with each score were as follows: a score of 0, 115 patients (7 percent); 1, 360 (22 percent); 2, 464 (29 percent); 3, 378 (23 percent); 4, 190 (12 percent); and 5 or higher, 111 (7 percent).

Legend C

Freedom from Progression of Disease in 1618 Patients According to Whether the Prognostic Score Was 0 to 2 or 3 or Higher

Reference:

Hasenclever D, Diehl V, Armitage J, Assouline D, Björkholm M, Brusamolino E et al. A Prognostic Score for Advanced Hodgkin's disease. NEJM 1998 Nov 19; 339(21): 1506-14.Copyright ©2008 Massachusetts Medical Society. All rights reserved.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.