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Clinical Development Programme

Besides the three phase 1/2 trials  that make up the clinical registration programme for larotrectinib to date, larotrectinib has also been included in two ongoing independent National Cancer Institute (NCI)-supported clinical trials (NCI-MATCH and NCI-COG Pediatric MATCH) that are screening and treating patients based on the genetic alterations in their tumours rather than based on tumour-type [1].

Table 8: Summary of Ongoing Clinical Trials for Larotrectinib

Registry Number

Name

Phase

Title

NCT03213704

Pediatric MATCH Treatment Trial

2

Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions

NCT02465060

MATCH Screening Trial

2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma

These data are current as of 6 June 2019 ( clinicaltrials.gov)

References

  1. Lassen UN, Albert CM, Kummar S et al. Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach. Annals of Oncology 2018; 29: mdy279.397-mdy279.397.

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