Drug-Drug Interactions with Kinase Inhibitors

Drug-Drug Interactions for Kinase Inhibitors

This section has been developed as a comprehensive resource providing information on the management of kinase inhibitor-associated drug-drug interactions.

At the time of the creation of this section (2015), there was a lack of current guidelines for managing drug-drug interactions with kinase inhibitors. Information included in this section is compiled from review of the medical literature and expert guidance from two clinical oncologists, Prof. Hans Gelderblom (Leiden University Medical Center, The Netherlands) and Prof. Claus-Henning Koehne (Klinikum Oldenburg, Germany), a  Clinical pharmacist, Dr. Roelof W F van Leeuwen (Erasmus MC Cancer Institute, The Netherlands), and a clinical pharmacologist, Dr. Vincent Launay-Vacher (Pitié-Salpêtrière University Hospital, Paris, France)

We therefore aim to:

  • Understand the clinically relevant drug-drug interactions with kinase inhibitors
  • Explore the type and mechanism of the interaction:  altered bioavailability due to altered stomach pH, metabolism by cytochrome P450 isoenzymes, and prolongation of the QTc interval   
  • Provide specific recommendations to guide physicians and clinical pharmacists in the management of drug-drug interactions during treatment with kinase inhibitors in daily clinical practice

These recommendations are based on the clinical experience and the best knowledge of the authors. By pursuing, you confirm that you have read and understand the disclaimer.

General Introduction

Information for healthcare professionals on drug-drug interactions associated with kinase inhibitor treatment of cancer

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Prophylaxis and Treatment

What professionals and patient should know and do in terms of prophylaxis and treatment of side effects associated with kinase inhibitor treatment

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