Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Previous Page Next Page

Due to endogenous and exogenous factors, such as UV radiation, ionizing radiation and genotoxic chemicals, DNA in every cell of the body is at constant risk of damage [1-3]. To overcome damage to DNA, repair pathways are needed. These pathways are collectively referred to as DNA damage response (DDR) [1, 4].

Click here for more information about the DDR

PARP is involved in DDR via several mechanisms [5-7]:

  • Repair of double-strand breaks through homologous recombination repair (HRR)
  • Non-homologous end joining (NHEJ)
  • Micro-homology mediated end joining (MMEJ; also known as alt-NHEJ).
  • Repair of single strand breaks (SSB) via base excision repair (BER).

Click here to find out more on what happens at the molecular level. 


  1. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature 2012; 481: 287-294.
  2. Friedberg EC. A brief history of the DNA repair field. Cell Res 2008; 18: 3-7.
  3. Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 2008; 26: 3785-3790.
  4. Lord CJ, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic. Science 2017; 355: 1152-1158.
  5. Moynahan ME, Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 2010; 11: 196-207.
  6. Murai J, Huang SY, Das BB et al. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res 2012; 72: 5588-5599.
  7. Cerrato A, Morra F, Celetti A. Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic. J Exp Clin Cancer Res 2016; 35: 179.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.