The DNA Damage Response (DDR) pathway coordinates the identification, signalling, and repair of DNA damage caused by endogenous or exogenous factors . It also integrates the regulation of cell cycle progression with DNA repair to minimize the chance of DNA damage being permanently passed on through cell division . Severe DNA damage that cannot be repaired may trigger apoptosis; as such the DDR pathway is of crucial importance as a cancer target.
Further information on DDR in health and disease and in cancer can be found by clicking on each topic below.
- Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461: 1071-1078.