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Proffered Paper - Supportive and palliative care

1810O - Impact of malnutrition according to the GLIM criteria in cancer patients admitted to hospital

Date

21 Sep 2020

Session

Proffered Paper - Supportive and palliative care

Presenters

Martin Nunez Abad

Citation

Annals of Oncology (2020) 31 (suppl_4): S988-S1017. 10.1016/annonc/annonc291

Authors

M. Nunez Abad1, J. Garrido Gallego1, V. Iranzo1, C. Caballero Diaz1, A. Fernandez Diaz1, I. Shaheen1, M. Meri Abad2, M. Franco La Rosa1, C. Garcia Gonzalez1, V. Ruiz Cordero1, L. Sanz Monge1, A. Jimenez Portilla3, A. Artero Fullana4, N. Prieto Colodrero5, B. Voltas Arribas4, Y. Ruiz Berjaga4, M. Llamas Montero4, C. Sanchez Juan4, C.J.C. Camps Herrero1, B.T. Muresan4

Author affiliations

  • 1 Medical Oncology, Hospital General Universitario Valencia, 46014 - Valencia/ES
  • 2 Medical Oncology, Hospital General Universitario Valencia, 46021 - Valencia/ES
  • 3 Endocrinology And Nutrition, Fundación de Investigación Hospital General Universitario de Valencia, 46014 - Valencia/ES
  • 4 Endocrinology And Nutrition, Hospital General Universitario Valencia, 46014 - Valencia/ES
  • 5 Biology, Fundación de Investigación Hospital General Universitario de Valencia, 46014 - Valencia/ES
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Resources

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Abstract 1810O

Background

Recently, the Global Leadership Initiative on Malnutrition (GLIM) criteria were proposed to standardize the diagnosis of malnutrition. We aim to determine the nutritional status and the prevalence of malnutrition in cancer inpatients as measured by GLIM criteria, and establish the association between malnutrition with the risk of nosocomial infections (NI) and length of hospital stay.

Methods

Prospective observational study carried out in patients admitted to Oncology Department of General University Hospital of Valencia from November 2019 to March 2020. Nutritional status was evaluated within the first 48 hours after admission. Fat free mass index (FFMI) and phase angle (PA) was measured using a bioelectrical impedance (Akern®), and muscle function using a Jamar® handgrip. Sarcopenia was measured using the cut-off values according to EWGSOP2.

Results

A total of 107 patients were evaluated (mean age 66 years, 66.4% males). Most patients (70.1%) had an advanced disease. On admission, 48 patients (44.9%) presented severe malnutrition and 19 (17.8%) moderate malnutrition based on GLIM criteria. In addition, 77 patients (72%) presented dynapenia and 18 patients (16.8%) sarcopenia. Other parameters of nutritional status were: mean weigh: 67.8 kg, mean BMI: 24 kg/m2, mean FFMI: 18.6 kg/m2 and mean PA: 4.5º. Mean length of stay was 13.9 days. During admission, 43 patients (40,2%) developed a NI, mostly respiratory tract infections (26 patients). Weigh, BMI and FFMI but not PA was significantly lower in patients who developed a NI (p<0.05 in all cases). The proportion of infections was higher in patients with severe malnutrition (25/48, 52.1%) and moderate malnutrition (8/19, 42.1%) as compared with patients with no malnutrition (10/40, 25%), (p=0,035). NI were more common in patients with sarcopenia (61.1% vs. 36%, p=0,044). Length of stay was longer in infected patients (18.6 vs 10.8 days, p<0,024) but was not related to nutritional status.

Conclusions

The prevalence of malnutrition in cancer inpatients is high. Malnutrition measured by GLIM criteria and sarcopenia are associated with a high risk of NI. An adequate nutritional evaluation is essential for a timely implementation nutritional support, to avoid malnutrition, sarcopenia and decrease NI.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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