Abstract 4906
Background
The role of the adaptive immune response in tumors has been widely explored.TILs are related with a better survival in several tumors. In ephitelial ovarian cancer (EOC) there are few data focusing on the effects of neoadjuvant chemotherapy (NACT) on T-cell infiltration, with controversial results.TILs may represent a prognostic and predictive biomarker and may have a role in selecting patients for immunotherapy.
Methods
We retrospectively evaluated 131 patients with stage IIIC-IV EOC who received NACT with platinum and taxane, interval debulking surgery (IDS) and chemotherapy post IDS.14 patients were excluded due to complete response. Stromal and Intratumoral TILs (sTILs-iTILs) were evaluated in tumor biopsies (pre NACT samples) and on residual disease post surgery (post NACT samples), using the criteria defined by the International TILs Working Group. The objective of the study was evaluating whether NACT could determine an increase T-cell infiltration with a consequent positive effect on outcome.
Results
Median follow up was 70.25 months.OS at 2 and 5 years were 68.6% (95%CI: 61.0%-77.1%) and 26.8% (95%CI:19.5%-36.8%) respectively.In the final analysis 50 patients were excluded due to the lack of suitable pre NACT samples.There was no association between sTILS or iTILs values assessed on pre and/or post NACT samples with OS (HR = 0.99; HR = 1.01 respectively) and PFS (HR = 0.99; HR = 1.002 respectively). However, investigating the difference of sTILs between post (median 12; IQR 6-20) and pre NACT samples (median 7; IQR 3.25-17), we found that an increase in sTILs in post NACT compared to pre NACT samples was associated with reduced mortality risk (HR = 0.71; 95% CI: 0.50-1.00 p = 0.05).Furthermore a no-linear association between the difference between post and preNACT iTILs and OS was detected (p = 0.11).
Conclusions
These findings, although limited by the small sample size and the retrospective nature of this analysis, suggest a possible role of TILs detected in residual tumor after NACT as prognostic biomarker in EOC. Further data are needed in order to confirm the role of TILs after NACT and their possible relevance to predict efficacy of immunotherapeutic strategies in this setting.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Nicoletta Colombo, Sara Giovannoni.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
2860 - Prognostic value of metabolic response assessed by 18FDG-PET after induction chemotherapy and after chemoradiotherapy (CRT) in localized esophageal squamous cell carcinoma (ESCC) patients (pts) receiving definite CRT (dCRT)
Presenter: Yeonghak Bang
Session: Poster Display session 2
Resources:
Abstract
3881 - Comprehensive genomic profiling of early-stage esophageal squamous cell carcinoma
Presenter: Jing Zuo
Session: Poster Display session 2
Resources:
Abstract
3944 - A novel nomogram and risk classification system predicting radiation pneumonitis in patients with esophageal cancer receiving radiotherapy
Presenter: Lu Wang
Session: Poster Display session 2
Resources:
Abstract
1956 - Drinking alcohol, smoking, multiple dysplastic lesions and the risk of field cancerization of squamous cell carcinoma in the esophagus and head and neck region
Presenter: Chikatoshi Katada
Session: Poster Display session 2
Resources:
Abstract
2144 - Neoadjuvant chemotherapy can eliminate the negative impact of postoperative infectious complications on recurrence in patients with esophageal cancer
Presenter: Kazuki Kano
Session: Poster Display session 2
Resources:
Abstract
2403 - Comparison of chemoradiotherapy (CRT) followed by consolidation with cisplatin and 5-fluorouracil (CF) versus definitive CRT with carboplatin and paclitaxel (CP) in esophageal cancer
Presenter: Marcelle Cesca
Session: Poster Display session 2
Resources:
Abstract
3247 - Paclitaxel in Combination with Cisplatin and 5-fluorouracil(TPF) Induction Chemotherapy for Locally Advanced Borderline-resectable Esophageal Squamous cell Carcinoma: A Phase II Clinical Trial
Presenter: Yuhong Li
Session: Poster Display session 2
Resources:
Abstract
4293 - Prognosis of esophageal squamous cell carcinoma based on local immunity evaluation
Presenter: Elena Zlatnik
Session: Poster Display session 2
Resources:
Abstract
5419 - Impact of Sarcopenia and adiposity in survival of metastatic esophageal cancer (MEC)
Presenter: Aline Fares
Session: Poster Display session 2
Resources:
Abstract
2083 - PALAESTRA - A phase II trial with short-course radiotherapy followed by chemotherapy as palliative treatment in esophageal adenocarcinoma
Presenter: David Borg
Session: Poster Display session 2
Resources:
Abstract