Abstract 2344
Background
The Economist Intelligence Unit takes a strategic approach to understand the impact of policy on lung cancer. Recommendations from our research, sponsored by MSD, will assist countries to improve systemic responses because outcomes remain poor and costs remain high despite scientific progress.
Methods
Our research centres on 13 countries: Austria, Belgium, Finland, France, Germany, Greece, Netherlands, Norway, Poland, Romania, Spain, Sweden, and the UK. Our literature review drew evidence from internationally-recognised sources and falls into 5 domains operationalised by 17 indicators assessing performance across the entire patient journey. After consultation with European experts, we populated our scorecard comparing policy and practice, examining service delivery, systems, access, financing and governance. Examination of preliminary findings in country workshops with clinicians, patient organisations and other key stakeholders enabled us to obtain nuanced information providing a clearer grasp on care than obtained from desk research alone.
Results
While patches of good practice exist, no country scores highly across all of our measurements. All but one country has a national cancer control plan: 75% are over five years old and do not incorporate recent oncological innovations. Clinical guidelines lack details on accelerating suspected lung cancer patients for diagnosis, referral pathways to secondary/tertiary care, supportive/palliative care, shared decision-making and psychological support within a specified time. Cancer registries exist in each country, yet clinicians report that clinically-focused cancer registries could house important information. Only 5 countries reimburse all four commonly used biomarkers for lung cancer.
Conclusions
Room for improvement in lung cancer policy exists across all the countries and domains we have studied. Our workshops ensured we focus on the most important opportunities for improving the delivery of lung cancer care relevant for each country. Now, based on the recommendations coming out of the research and agreed upon by stakeholders, we are in the policy development phase of our work where our goal is to assist policymakers improve care for people living with lung cancer in Europe.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
MSD.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1802 - Evaluation of the anti-tumor efficacy and immune effects of N-809, a novel IL-15 superagonist/anti-PD-L1 bispecific agent
Presenter: Kristin Hicks
Session: Poster Display session 3
Resources:
Abstract
3190 - GI101, a novel triple-targeting bispecific CD80-IgG4-IL2variant fusion protein, elicits synergistic anti-tumor effects in preclinical models
Presenter: Jae Chan Park
Session: Poster Display session 3
Resources:
Abstract
4062 - Phase 1b, open-label, dose-escalation study of M9241 (NHS-IL12) plus avelumab in patients (pts) with advanced solid tumors
Presenter: Julius Strauss
Session: Poster Display session 3
Resources:
Abstract
5777 - THOR-707, a novel not-alpha IL-2, promotes all key immune system anti-tumoral actions of IL-2 without eliciting vascular leak syndrome (VLS)
Presenter: Marcos Milla
Session: Poster Display session 3
Resources:
Abstract
5047 - A phase I clinical trial of malignant pleural mesothelioma treated with locally delivered autologous anti-FAP-targeted CAR T-cells
Presenter: Alessandra Curioni
Session: Poster Display session 3
Resources:
Abstract
1679 - HPV16 E6-specific TCR-T armored with checkpoint blockade in the treatment of cervical cancer
Presenter: Paul Bryson
Session: Poster Display session 3
Resources:
Abstract
1133 - the Mutant Neoantigen Specific T Cell Is a Personalized Immunotherapy in Refractory Solid Tumor
Presenter: Qi Song
Session: Poster Display session 3
Resources:
Abstract
3338 - NY-ESO-1 and LAGE1A –an emerging target for cell therapies in solid tumours
Presenter: Ioanna Eleftheriadou
Session: Poster Display session 3
Resources:
Abstract
3089 - Targeting myeloid-derived suppressor cells and T cells: combination treatment with MTL-CEBPA and PD-1 antibody in a mouse syngeneic CT26 model
Presenter: Mikael Sodergren
Session: Poster Display session 3
Resources:
Abstract
5991 - Master Checkpoint Cbl-b Inhibition: Anti-tumor Efficacy in a Murine Colorectal Cancer Model Following siRNA-based Cell Therapy
Presenter: Kathrin Thell
Session: Poster Display session 3
Resources:
Abstract