1801 - Implementation Frameworks to effectively transition complex research interventions into clinical practice in Oncology, Nuclear Medicine, Diagnostic and Interventional Radiology; A scoping Systematic Review

Background

Clinical research is considered as a cross-disciplinary specialty in modern day medicine merging science and clinical arenas to better public health. The rapidly changing clinical research landscape has led to an array of treatments moving towards a precision medicine platform involving complex interventions. Thus, clear processes to conduct and transition research interventions into clinical practice are more important than ever. Theoretically, implementation of novel interventions require clear methods as part of a fit for purpose framework comprising of effective adaptation processes and practice policies. However, from a practical perspective, implementation of new interventions is more complex especially in specialties such as oncology, NM, IR and DR. This is the first study to systematically scope and review implementation frameworks to understand it’s applicability in clinical specialties.

Methods

We searched 17 databases including PubMed, Medline/OvidSP, Science Direct, PROSPERO, PRISMA, PubMed Health, Embase, EBSCOhost, SciELO, TRIP, ProQuest, Academic search complete, Ageline, Cochrane, Web-of-Science and BIOSIS using a comprehensive search strategy to review publications from January 1^st1980 to 31^stMarch 2019 in English. We selected 20 publications as per the inclusion/exclusion criteria developed under a review protocol registered with PROSPERO (CRDG42019124020).

Results

There were no publications indicating a validated framework or a specific system used to implement complex interventions within oncology, IR, NM and DR. However, there were generalized implementation processes and adaptation models available. Furthermore, validation studies were not conducted against these frameworks to review their applicability and viability in healthcare especially in the UK.

Conclusions

It is evident there is a research implementation gap in healthcare especially in the UK and additional operational research is required to address this issue. Better alignment between academic theories and healthcare practice is also required to enable better implementation of novel interventions.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.