ESMO Asia Virtual Congress 2020

Abstract 247P

Background

To determine the p53 gene suppressor and bcl-2 oncoprotein forecast role in non-epithelial ovarian tumor prognosis among child and adolescent patients.

Methods

Our search is based on immunohistochemical method results of 35 patients with non-epithelial ovarian tumors at I-IV stages, which were diagnosed and treated in oncogynecology and children oncology departments .

Results

The analysis of immunohistochemical method results shows 7(20%) patients among which had been marked high expression bcl-2 oncoprotein, 11(31,4%) moderate express, 16(45,7%) low express. Analysis of p53 gene suppressor results shows 9(25,7%) patients among which had been marked high expression, 11(31,4%) moderate express, 15(42,8%) low express. The high correlation between bcl-2 expression level increases and fast tumor growth, and therefore incurability of oncologic process among of patients had been revealed. Also the high probability of tumor recurrence was noticed. In the high-positive p53 gene suppressor rate group took place aggressive current of tumor process and these patients had early recurrence and metastases, which demanded recurrent aggressive chemotherapy

Conclusions

p53 gene suppressor and bcl-2 oncoprotein expression in non-epithelial ovarian tumors among the child and adolescent patients is characterized with high and low rates, which enables to use this rate determination for given pathology currency prognosis identification.