374O - The burden and trends of gynecological cancers in Asia from 1980 to 2021: A systematic analysis for the global burden of disease study 2021

Background

Gynecological cancers contribute a major proportion of maternal mortality and are among the most prevalent cancers in women worldwide. This study aims to analyze the burden of three gynecological cancers (cervical cancer, uterine cancer, and ovarian cancer) in Asia from 1980 to 2021.

Methods

We conducted this cross-sectional study based on the Global Burden of Disease 2021 database (GBD 2021). We obtained the incidence, mortality rates, and DALYs as indicators to estimate the burden. We used the age-period-cohort web tool (APC-Web) to analyze the effects of age, period, and cohort on the incidence of gynecological cancers. The burden of gynecological cancers in Asia from 2025 to 2050 was predicted using a Bayesian age-period-cohort (BAPC) model.

Results

In Asia, cervical cancer had the highest age-standardized burden in 2021, with a mortality rate of 3.1 deaths (95% CI: 2.7-3.4) per 100,000 population, while uterine cancer had the lowest, with a mortality rate of 0.7 deaths (95% CI: 0.6-0.9) per 100,000. For cervical cancer, the most affected region was South Asia. The nation with the highest burden was Seychelles, followed by Mongolia, Cambodia, and Nepal. For ovarian cancer, the most affected region was Central Asia. The nation with the highest burden was Georgia, followed by United Arab Emirates, Seychelles, and Brunei Darussalam. For uterine cancer, the most affected region was Central Asia. The nation with the highest burden was Georgia, followed by Armenia, Mauritius, and United Arab Emirates. Using the APC-Web tool, we found that the burden of these three gynecological cancers roughly decreased from 1980 to 2021 across most age groups and the average annual precent changes of cervical cancer, uterine cancer, and ovarian cancer were -1.54, -0.94, and 0.37, respectively. In addition, we predicted increasing trends of the gynecological cancers burden in all age groups from 2025 to 2050, with women aged 60 to 64 years being the most affected.

Conclusions

Our study indicated the mortality rates of three main gynecological cancers across different regions of Asia. Our prediction revealed an increasing trend in the burden of these cancers.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.