ESMO Asia Congress 2022

Abstract 240P

Background

This study aimed to investigate the role of the serpin peptidase inhibitor, clade E, member 2 (SERPINE2), in patients with oral squamous cell carcinoma (OSCC).

Methods

We investigated SERPINE2 mRNA expression in cases of squamous cell carcinoma from online databases, explored the relationship between SERPINE2 and clinicopathological characteristics and prognosis in OSCC patients, and determined the potential of SERPINE2 to affect OSCC proliferation, migration and invasion capability in vitro.

Results

The expressions of SERPINE2 were higher in tumor tissues than that in normal tissues in TNMplot. High mRNA expression of SERPINE2 was significantly correlated with poor overall 5-year survival in KmPlot. High SERPINE2 immunoexpression was significantly correlated with adverse pathologic parameters. High SERPINE2 immunoexpression was significantly associated with worse overall survival. SERPINE2 promotes cell proliferation, cell migration, and invasion ability in OSCC cell lines. Table: 240P

Relationships between the immunoscore of SERPINE2 and clinicopathological parameters in 122 patients

Parameters	No.	Mean ± SEM	Median	p
Age^a
≤ 54	73	147.47 ± 7.77	160	0.132
> 54	49	163.83 ± 8.86	165
Gender^a
Male	107	152.59 ± 6.45	160	0.561
Female	15	164.33 ± 13.21	160
Tumor site^b
Buccal	77	152.08 ± 7.29	160	0.700
Retromolar	24	148.96 ± 13.50	165
Tongue	7	170.36 ± 25.33	170
Others	14	165.36 ± 19.25	171
Histological grade^b
Well	45	149.00 ± 8.18	165	0.720
Moderate	71	156.13 ± 8.35	160
Poor	6	167.08 ± 30.81	183
Stage^a
I–II	66	133.60 ± 7.41	153	<0.001*
III–IV	56	178.13 ± 8.34	184
Tumor status^a
T1–2	78	139.20 ± 7.18	160	<0.001*
T3–4	44	180.34 ± 8.98	186
Nodal metastasis^a
Absent	91	145.36 ± 6.39	160	0.011*
Present	31	179.52 ± 12.64	180
Distant metastasis^a
Absent	107	148.69 ± 6.36	160	0.010*
Present	15	192.17 ± 11.12	188

^ap-value by Mann–Whitney U test^bp-value by Kruskal–Wallis test. *Significance at p < 0.05

Conclusions

Our results suggest that SERPINE2 may serve as a prognostic biomarker, associated with the tumorigenesis and aggressiveness of OSCC, and a potential therapeutic target in oral cancer.