ESMO Asia Congress 2022

Abstract 115P

Background

Cholangiocarcinoma is the most common primary cancer of liver in North-Eastern region of Thailand. Human epidermal growth factor receptor-2 (HER-2) overexpression is a poor prognostic factor of many types of cancer but there is limited data in cholangiocarcinoma. This study aimed to investigate prevalence of HER-2 overexpression in cholangiocarcinoma and analyzed its association with overall survival and clinicopathological features.

Methods

This study was retrospective cohort analytical single-centered study which included adult patients with cholangiocarcinoma in Srinagarind hospital, Khon Kaen, Thailand. HER-2 expression was classified as positive and negative group. Prevalence of HER-2 overexpression was presented with percentage and 95% confidence interval (95% CI).

Results

A total of 93 cases, of which 71% were male, were included. Mean age was 63 and 62 years in HER-2 positive and negative groups, respectively. The proportion of intrahepatic was more than extrahepatic cholangiocarcinoma (72% vs 28%). HER-2 positive was revealed 10.8% (95% CI 5.3% to 18.9%), composed of 9 cases (13.4%) of patients with intrahepatic cholangiocarcinoma and 1 case (3.8%) of patients with extrahepatic cholangiocarcinoma. The prevalence of HER-2 staining intensity 2+ and 1+ were 14.0% (13 cases) and 15.1% (14 cases), respectively. Median overall survival was not reach in HER-2 positive group compared with 30.9 months in negative group. (hazard ratio 0.39; 95% CI 0.12 to 1.21; p 0.089). This study could not demonstrate association between HER-2 positive and any clinicopathological features.