115P - Human epidermal growth factor receptor-2 (HER-2) expression status in patients with cholangiocarcinoma

Background

Cholangiocarcinoma is the most common primary cancer of liver in North-Eastern region of Thailand. Human epidermal growth factor receptor-2 (HER-2) overexpression is a poor prognostic factor of many types of cancer but there is limited data in cholangiocarcinoma. This study aimed to investigate prevalence of HER-2 overexpression in cholangiocarcinoma and analyzed its association with overall survival and clinicopathological features.

Methods

This study was retrospective cohort analytical single-centered study which included adult patients with cholangiocarcinoma in Srinagarind hospital, Khon Kaen, Thailand. HER-2 expression was classified as positive and negative group. Prevalence of HER-2 overexpression was presented with percentage and 95% confidence interval (95% CI).

Results

A total of 93 cases, of which 71% were male, were included. Mean age was 63 and 62 years in HER-2 positive and negative groups, respectively. The proportion of intrahepatic was more than extrahepatic cholangiocarcinoma (72% vs 28%). HER-2 positive was revealed 10.8% (95% CI 5.3% to 18.9%), composed of 9 cases (13.4%) of patients with intrahepatic cholangiocarcinoma and 1 case (3.8%) of patients with extrahepatic cholangiocarcinoma. The prevalence of HER-2 staining intensity 2+ and 1+ were 14.0% (13 cases) and 15.1% (14 cases), respectively. Median overall survival was not reach in HER-2 positive group compared with 30.9 months in negative group. (hazard ratio 0.39; 95% CI 0.12 to 1.21; p 0.089). This study could not demonstrate association between HER-2 positive and any clinicopathological features.

Conclusions

Among patients with cholangiocarcinoma, 1 of 10 cases had HER-2 overexpression.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

This study was granted by Faculty of Medicine, Khon Kaen University, Thailand (Grant Number IN64140).

Disclosure

All authors have declared no conflicts of interest.