Abstract 500P
Background
With the advances of next-generation sequencing (NGS), compound EGFR mutations were more frequently observed. Prior studies reported that patients with compound EGFR mutations showed poor clinical outcome. However, molecular and clinical features of NSCLC patients harboring such mutations were poorly investigated.
Methods
A total of 1091 primary NSCLC patients were enrolled. Variants of EGFR and other driver genes were analyzed by NGS. EGFR exon 19 deletion (19 del) and L858R mutations were defined as common sensitizing mutations; EGFR G719S/C/A mutations were defined as uncommon sensitizing mutations; other mutations were defined as rare mutations. Patients were divided as follows: common sensitizing and rare mutations (group A); uncommon sensitizing and rare mutations (group B); double rare mutations (group C).
Results
Overall, EGFR mutations were detected in 418 patients (38.3%), and 76 cases (7.0%) carried compound EGFR mutations. Frequencies of group A, B and C were 76.3%, 18.4% and 5.3%, respectively, indicating compound mutations mainly consist of sensitizing and atypical mutations. Compound mutations were more frequently observed in young patients (p = 0.017), and distributions of the three groups were different between early and adavanced stages (p = 0.032). According to types of common sensitizing mutations, rate of compound mutations harboring EGFR L858R alteration was strikingly higher than that carrying EGFR 19 del alteration (p = 0.039). Further analysis demonstrated that frequency of EGFR T790M mutation among the three groups showed significant difference (p = 0.031). Genomic data revealed TP53 mutations markedly coexisted with compound mutations compared with single mutation (p = 0.03). Moreover, relative EGFR mutant allele frequency (rMAF) of group A, calculated as MAF of EGFR sensitizing mutations / MAF of EGFR rare mutations, was higher than that of group B (p = 0.007).
Conclusions
This study comprehensively explored the population characteristics of compound EGFR mutations from a large cohort of primary NSCLC patients, which will be helpful to guide personalized therapy and promote the clinical management of this population.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
H. Cheng: Honoraria (self): Beijing Acornmed Biotechnology Co., Ltd. H. Wang: Honoraria (self): Beijing Acornmed Biotechnology Co., Ltd. F. Lou: Honoraria (self): Beijing Acornmed Biotechnology Co., Ltd. S. Cao: Honoraria (self): Beijing Acornmed Biotechnology Co., Ltd. All other authors have declared no conflicts of interest.
Resources from the same session
64P - Entrectinib in locally advanced/metastatic ROS1 and NTRK fusion-positive non-small cell lung cancer (NSCLC): Updated integrated analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Presenter: Filippo de Braud
Session: Poster display session
Resources:
Abstract
65P - Updated efficacy and safety of entrectinib in patients with NTRK fusion-positive tumours: Integrated analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Presenter: Christian Rolfo
Session: Poster display session
Resources:
Abstract
66P - Brain metastases, treatment patterns and outcomes in ROS1-positive NSCLC patients from US oncology community centers
Presenter: Matthew Krebs
Session: Poster display session
Resources:
Abstract
67P - Pooled safety analysis of tepotinib in Asian patients with advanced solid tumours
Presenter: Kentaro Yamazaki
Session: Poster display session
Resources:
Abstract
68P - A novel anti-EGFR antibody HLX07 for potential treatment of squamous cell carcinoma of the head and neck
Presenter: Ming Mo Hou
Session: Poster display session
Resources:
Abstract
69P - Irinotecan and cisplatin therapy-induced neutropenia as a prognostic factor in patients with extensive-disease small cell lung cancer
Presenter: Hiroshi Ishikawa
Session: Poster display session
Resources:
Abstract
70P - Is safe and efficient by intraoperative endoscopic nasobiliary drainage over primary closure of the common bile duct for cholecystolithiasis combined with common bile duct stones: A meta-analysis
Presenter: Jiasheng Cao
Session: Poster display session
Resources:
Abstract
71P - Irreversible electroporation versus radiotherapy after induction chemotherapy on survival in patients with locally advanced pancreatic cancer: A propensity score analysis
Presenter: Chaobin He
Session: Poster display session
Resources:
Abstract
72P - Novel technique of near-focus mode for accurate operation during endoscopic submucosal tunneling procedure: A two-center comparative study
Presenter: Wei Peng
Session: Poster display session
Resources:
Abstract
73P - Cabozantinib in combination with anti-PD1 immune checkpoint inhibitor in syngeneic tumour mouse models
Presenter: Rachel Sparks
Session: Poster display session
Resources:
Abstract