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Poster display session

71P - Irreversible electroporation versus radiotherapy after induction chemotherapy on survival in patients with locally advanced pancreatic cancer: A propensity score analysis

Date

23 Nov 2019

Session

Poster display session

Topics

Clinical Research

Tumour Site

Pancreatic Adenocarcinoma

Presenters

Chaobin He

Citation

Annals of Oncology (2019) 30 (suppl_9): ix22-ix29. 10.1093/annonc/mdz420

Authors

C. He

Author affiliations

  • Department Of Hepatobiliary And Pancreatic Surgery, Sun Yat-sen University Cancer Center, 510060 - Guangzhou/CN

Resources

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Abstract 71P

Background

Locally advanced pancreatic cancer (LAPC) represents more than one third of pancreatic cancers and owns poor survival after the standard chemotherapy. Irreversible electroporation (IRE) is a novel method and has been recently used in LAPC. The aim of this study was to compare the efficacy of IRE and radiotherapy after induction chemotherapy for patients with LAPC.

Methods

From August 2015 to August 2017, a total of 76 patients with biopsy proven LAPC and who had received IRE or radiotherapy after chemotherapy were included. Thirty-two pairs of patients were selected through propensity score matching (PSM) analysis and the efficacy of two treatments was compared.

Results

Before PSM analysis, after induction chemotherapy, patients with LAPC benefited more in terms of overall survival (OS) and progression free survival (PFS) from IRE, compared with radiotherapy (2-year OS rates, 53.5% vs 26.9%, p = 0.039; 2-year PFS rates, 28.4% vs 13.3%, p = 0.045). After PSM analysis, the survival benefits of OS and PFS of patients after induction chemotherapy followed by IRE were more obvious than those of patients treated with radiotherapy (2-year OS rates, 53.5% vs 20.7%, p = 0.011; 2-year PFS rates, 28.4% vs 5.6%, p = 0.004). Multivariate Cox regression analysis indicated that IRE after induction chemotherapy was identified as a significant favourable factor for both OS and PFS in both the whole and matched cohort. Comparison of toxicity and complications between two groups.Table: 71P

ComplicationsChemotherapy + IREChemotherapy + radiotherapyP value
All3636
Toxicity
Neutropenia1120.001
Lymphopenia2100.024
Hypoalbuminemia370.307
Hypotension350.710
Hypokalemia270.151
Fatigue2100.024
Vomiting090.002
Diarrhea290.046
Complications
Thrombosis450.890
Ascites160.107
Abdominal pain280.085
Muscle weakness1100.006

Conclusions

Induction chemotherapy followed by IRE is superior to induction chemotherapy followed by radiotherapy for treating LAPC. A randomized clinical trial comparing the efficacy of IRE and radiotherapy after the induction chemotherapy is therefore considerable.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Chaobin He.

Funding

National Natural Science Foundation of China (81171890; 81672390), and the Major National Scientific Research Projects of China (No. 2013CB910304).

Disclosure

All authors have declared no conflicts of interest.

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