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Poster Display session 2

3426 - High dose Neo-adjuvant chemotherapy in Triple-Negative breast cancer with evidence of homologous recombination deficiency (HRD).

Date

29 Sep 2019

Session

Poster Display session 2

Presenters

Sonja Vliek

Citation

Annals of Oncology (2019) 30 (suppl_5): v55-v98. 10.1093/annonc/mdz240

Authors

S.B. Vliek1, E. Van Werkhoven2, I. Mandjes3, T. Westphal3, E.H. Lips1, L. Mulder1, C. Loo4, N. Russel5, M. Holtkamp6, M. Schot6, J. Baars7, M. Karger6, A.H. Honkoop8, M.E.M.M. Bos9, A.L.T. Imholz10, S. Vrijaldenhoven11, V. Dezentje6, P.M. Nederlof12, S.C. Linn6

Author affiliations

  • 1 Molecular Pathology, The Netherlands Cancer Institute, 1066 CX - Amsterdam/NL
  • 2 Biometrics, The Netherlands Cancer Institute, 1066CX - Amsterdam/NL
  • 3 Biometrics, The Netherlands Cancer Institute, 1066 CX - Amsterdam/NL
  • 4 Radiology, The Netherlands Cancer Institute, 1066 CX - Amsterdam/NL
  • 5 Radiation Oncology, The Netherlands Cancer Institute, 1066 CX - Amsterdam/NL
  • 6 Medical Oncology, The Netherlands Cancer Institute, 1066 CX - Amsterdam/NL
  • 7 Medical Oncology, The Netherlands Cancer Institute, Amsterdam/NL
  • 8 Internal Medicine, Isala Klinieken, 8025 AB - Zwolle/NL
  • 9 Medical Oncology, ErasmusMC, Rotterdam/NL
  • 10 Internal Medicine, Deventer Ziekenhuis, 7416 SE - Deventer/NL
  • 11 Internal Medicine, Northwest Clinics, 1800 AM - Alkmaar/NL
  • 12 Molecular Diagnostics, The Netherlands Cancer Institute, 1066 CX - Amsterdam/NL
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Resources

Abstract 3426

Background

Subgroup analyses of randomized, controlled trials (RCTs) using high dose chemotherapy (HD) with autologous stem cell support (autoSCT) reveal a potential benefit of HD in patients with triple negative breast cancer (TNBC) and in tumors harboring features of HRD (Vollebergh et al, 2011). The phase III part of the neo-TN RCT, compared neo-adjuvant HD with conventional treatment (CONV) in BRCA1-like TNBC.

Methods

Patients with cT2-3N0-3M0 TNBC with HRD were randomized between HD or CONV after 3 courses of 2-weekly doxorubicin/cyclophosphamide (ddA60C600). CONV treatment consisted of another 3xddAC, or in case of an unfavorable response on MRI a switch to 3 cycles capecitabine800BID14-7/docetaxel75; after an amendment all patients switched to 3xcarboplatinAUC6/paclitaxel80weekly. The HD regimen consisted of a 4th course ddAC and 2 courses of cyclophosphamide3000d1/carboplatin400d1,2/ thiotepa250d2 both followed by autoSCT. Primary outcome was the Neo-adjuvant Response Index (NRI), secondary outcomes included overall (OS) and recurrence free survival (RFS).

Results

From 2010 to 2016, 122 patients were randomized (intention-to-treat). Median follow-up is 45 months. There was no significant difference in NRI between HD and CONV (mean NRI 0.78 versus 0.72, range 0-1, p = 0.41 Wilcoxon test). An NRI of > 0.7 was strongly associated with good prognosis (RFS of 97% [95%CI 93%-100%] versus 67% [95%CI 55%-82%] at 4 years). See Table for 4-years OS and RFS comparing HD with CONV. There were no treatment related deaths. However, 7 out of 55 patients who actually received HD did not complete HD mainly because of infections or allergic reactions.Table:

187P

HD % (95%CI)CONV % (95%CI)HR (95%CI)p-value
All (n = 122)
4-yrs OS 4-yrs RFS92 (85-99) 92 (85-99)79 (69-91) 78 (68-89)0.43 (0.15-1.23) 0.41 (0.15-1.07)0.12 0.07
Stage III only (n = 35)
4-yrs OS93 (81-100)60 (39-93)0.14 (0.02-1.14)0.07

Conclusions

No significant efficacy differences were found between HD and CONV. The NRI is of prognostic value. Whether the HD regimen is promising, especially in very high risk BRCA1-like TNBC [HR = 0.14], requires additional data including a comparison with platinum treatment in all control arm patients.

Clinical trial identification

NCT01057069.

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

The Dutch Cancer Foundation (KWF) and by the Schumacher Kramer Foundation.

Disclosure

S.C. Linn: Research grant / Funding (self), research support for patients fees in D-Care study: Amgen; Advisory / Consultancy, Research grant / Funding (self), Research grant / Funding (institution): AstraZeneca; Advisory / Consultancy: Cergentis; Research grant / Funding (self): Genentech; Advisory / Consultancy: IBM; Research grant / Funding (self): Novartis; Advisory / Consultancy, Research grant / Funding (institution), patients fees in TEAM 2b study: Pfizer; Advisory / Consultancy, Research grant / Funding (self), Research grant / Funding (institution): Roche; Research grant / Funding (institution): Tesaro; Speaker Bureau / Expert testimony, Fee for teaching, paid to institution: Bayer. All other authors have declared no conflicts of interest.

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