Chapter 1 - Histopathology of Gynaecological Cancers
- Ovarian tumours:
- Epithelial ovarian tumours
- Sex cord ovarian tumours
- Germ cell ovarian carcinomas
- Ovarian cancer is not a homogeneous disease, but rather a group of diseases—each with different morphology and biological behaviour. Reproducible histopathological diagnosis of tumour cell type is a conditio sine qua non for successful treatment. FIGO staging has recently been revised and reflects the tumour dissemination and subsequent prognosis
- Uterine corpus tumours:
- Type 1: Endometrioid carcinomas
- Type 2: Serous carcinomas
- In uterine corpus cancers, three major types can be identified according to their intrinsic biology and subsequent treatments: (1) epithelial, (2) mesenchymal and (3) mixed epithelial and mesenchymal
- Uterine cervical tumours:
- HPV and pre-invasive lesions
- Squamous carcinoma
- Cervical cancers mainly derive from high-risk HPV infections (mostly by HPV16/18). Here we describe the pathological features of the two principal subtypes: (1) squamous cell carcinoma, (2) adenocarcinomas
Bristow RE, Tomacruz RS, Armstrong DK, et al. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol 2002; 20:1248–1259.
Prat J; FIGO Committee on Gynecologic Oncology. Staging Classification for Cancer of the Ovary, Fallopian Tube, and Peritoneum: Abridged Republication of Guidelines From the International Federation of Gynecology and Obstetrics (FIGO). Obstet Gynecol 2015; 126:171–174.