ESMO Factsheets on Biomarkers

The ESMO Translational Research and Personalised Medicine Working Group has developed a number of factsheets of validated biomarkers designed to assist you in your daily practice. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarkers are key components of translational studies. Ideally, the development of targeted therapies should be closely coupled with the identification and validation of biomarkers.

In this section, you can find factsheets on biomarkers prepared by esteemed European experts with statements on:

  • Prognostic value
  • Predictive value
  • Testing recommendations
  • Ensuring quality and timely testing results
  • Patient selection

Watch Prof. Kerr explaining the pathologist's perspective

Read the article on immunology biomarkers by John Haanen

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Topic Title Author
GIST PDGFRA in Gastrointestinal Stromal Tumours (GIST) Antoine Italiano
GIST KIT and PDGFRA Wild-type Gastrointestinal Stromal Tumours (GISTs) Antoine Italiano
GIST KIT in Gastrointestinal Stromal Tumours (GIST) Antoine Italiano
Genitourinary Cancers - Urothelial Cancers - Head and Neck Cancers - Thoracic malignancies - Skin cancers PD-L1 in Cancer Hendrik-Tobias Arkenau
Immunotherapy - Personalised/Precision medicine - Basic Principles in the Management and Treatment (of cancer) - Therapy Tumour Mutational Load Nicola Normanno
Personalised/Precision medicine - Basic Principles in the Management and Treatment (of cancer) Multigene Sequencing for Treatment Selection Ivan Bièche, Maud Kamal, Christophe Le Tourneau
Thoracic malignancies T790M in NSCLC Nicola Normanno
Central Nervous System Malignancies IDH1/2 Mutations in Glioma Ahmed Idbaih, Mehdi Touat
Central Nervous System Malignancies 1p/19q Co-deletion in Glioma Mehdi Touat, Ahmed Idbaih
Gastrointestinal Cancers - Gynaecologic Malignancies Microsatellite Instability - Defective DNA Mismatch Repair Ivana Cataldo, Aldo Scarpa, Lisa Salvatore
Gastrointestinal Cancers - Colon and Rectal Cancer BRAF in Colorectal Cancer Teresa Troiani, Nicola Normanno, Stefania Napolitano
Gynaecologic Malignancies - Ovarian Cancer BRCA1 and BRCA2 in Ovarian Cancer Sabrina Chiara Cecere, Sandro Pignata
Thoracic malignancies ROS1 in Lung Cancer Keith Kerr
Breast Cancer ER in Breast Cancer Giuseppe Viale
Breast Cancer HER2 in Breast Cancer Giuseppe Viale