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ASCO 2023 Expert Report in HR positive, HER2 negative breast cancer by Catherine Harper-Wynne

Reporting from ASCO 2023, Catherine Harper-Wynne discusses the results from three important studies in HR+, HER2- Breast Cancer. The NATALEE trial investigating the addition of ribociclib to Endocrine Therapy (ET) in the adjuvant setting, shows promising but still early DFS results. In the metastatic setting, the SONIA study explores the possibility of using in first-line ET alone and then switching to CDK4/6 inhibitors with ET, vs the opposite. Addressing the issue of CDK4/6 inhibitors' efficacy as maintenance in second-line treatment, the PALMIRA study provides insights into their effectiveness in this context.

Abstracts discussed:
- LBA1000: Primary outcome analysis of the phase 3 SONIA trial (BOOG 2017-03) on selecting the optimal position of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors for patients with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC).
- LBA500: Phase III NATALEE trial of ribociclib + endocrine therapy as adjuvant treatment in patients with HR+/HER2− early breast cancer.
- Abstract 1001: Second-line endocrine therapy (ET) with or without palbociclib (P) maintenance in patients (pts) with hormone receptor-positive (HR[+])/human epidermal growth factor receptor 2-negative (HER2[-]) advanced breast cancer (ABC): PALMIRA trial.

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