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International Prognostic Index for Agressive Non-Hodgkin's Lymphoma

The International Non-Hodgkin's Lymphoma Prognostic Factor Project was undertaken to develop a model for predicting outcomes in patients with aggressive non-Hodgkin's lymphoma on the basis of the patients' clinical characteristics before treatment. Two indexes (the International Prognostic Index and age-adjusted index), were significantly more accurate than the Ann Arbor classification in predicting long-term survival.

Risk factors for the Definition of the International Prognostic Index (IPI)

General Index

Parameter

Age Adjusted Index

1

Age > 60 years

n.a.

1

PS 2-4

1

1

Stage 3-4

1

1

LDH elevated

1

1

Extra nodal >1 site

non considered

5

Maximum Score

3

Risk Groups of the International Prognostic Index

No. of Risk Factors

No. of Risk Factors

IPI Group

0 - 1

0

1 = low

2

1

2 = low intermediate

3

2

3 = high intermediate

4 - 5

3

4 = high

International Prognostic Index for Aggressive Lymphoma (General IPI)

IPI-lymphoma_02

Age adjusted International prognostic Index

IPI-ageadjusted_02

Copyright ©2008 Massachusetts Medical Society. All rights reserved. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A Predictive Model for Aggressive Non-Hodgkin's Lymphoma.
NEJM 1993, Sept 30, 329(14): 987-994.

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