The International Non-Hodgkin's Lymphoma Prognostic Factor Project was undertaken to develop a model for predicting outcomes in patients with aggressive non-Hodgkin's lymphoma on the basis of the patients' clinical characteristics before treatment. Two indexes (the International Prognostic Index and age-adjusted index), were significantly more accurate than the Ann Arbor classification in predicting long-term survival.
Risk factors for the Definition of the International Prognostic Index (IPI)
General Index |
Parameter |
Age Adjusted Index |
|---|---|---|
1 |
Age > 60 years |
n.a. |
1 |
PS 2-4 |
1 |
1 |
Stage 3-4 |
1 |
1 |
LDH elevated |
1 |
1 |
Extra nodal >1 site |
non considered |
5 |
Maximum Score |
3 |
Risk Groups of the International Prognostic Index
No. of Risk Factors |
No. of Risk Factors |
IPI Group |
|---|---|---|
0 - 1 |
0 |
1 = low |
2 |
1 |
2 = low intermediate |
3 |
2 |
3 = high intermediate |
4 - 5 |
3 |
4 = high |
International Prognostic Index for Aggressive Lymphoma (General IPI)
Age adjusted International prognostic Index
Copyright ©2008 Massachusetts Medical Society. All rights reserved. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A Predictive Model for Aggressive Non-Hodgkin's Lymphoma.
NEJM 1993, Sept 30, 329(14): 987-994.