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A prognostic tool for distinguishing risk groups in immunocompetent patients with primary CNS lymphomas (PCNSL). This tool is based on data from 378 PCNSL patients treated at 23 cancer centres from five different countries.

Risk factors for the Definition of the Prognostic Index of the IELSG

General Index




Age > 60y



PS 2-4

ECOG Performance Score


Serum LDH elevated

above upper normal


Cerebrospinal fluid protein elevated

above upper normal


Deep structures involved

basal ganglia, corpus callosum, brain stem, or cerebellum


Maximum Score

NOT evaluated for HIV+

Risk Groups of the IELSG Index

# of Risk Factors - General index

Risk Group

0 - 1

1 = low

2 - 3

2 = intermediate

4 - 5

3 = high

Reprinted with permission. ©2008 American Society of Clinical Oncology. All rights reserved. Ferreri AJM et al: Prognostic Scoring System for Primary CNS Lymphomas: The International Extranodal Lymphoma Study Group Experience J Clin Oncol Vol.21 (2), 2003: 266-272.

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