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We aim to cover the following topics:

  1. The mechanism of action of PARP inhibition and its role in the treatment of prostate cancer.
  2. Testing strategies to identify DNA Damage Repair (DDR) mutations in prostate cancer, and their prevalence and clinical relevance.
    • How to perform genetic counselling.
    • The difference between different genomic tests.
  3. Clinical efficacy and safety profile of PARP inhibitors for patients with prostate cancer.
    • Patient selection using genetic/genomic testing results.
    • The management of adverse events.
  4. The place of PARP inhibition in the prostate cancer treatment pathway and future developments.
    • The PARP inhibitors in development for prostate cancer.
    • The potential combination strategies with PARP inhibitors.

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