We aim to cover the following topics:
- The mechanism of action of PARP inhibition and its role in the treatment of prostate cancer.
- Testing strategies to identify DNA Damage Repair (DDR) mutations in prostate cancer, and their prevalence and clinical relevance.
- How to perform genetic counselling.
- The difference between different genomic tests.
- Clinical efficacy and safety profile of PARP inhibitors for patients with prostate cancer.
- Patient selection using genetic/genomic testing results.
- The management of adverse events.
- The place of PARP inhibition in the prostate cancer treatment pathway and future developments.
- The PARP inhibitors in development for prostate cancer.
- The potential combination strategies with PARP inhibitors.