PARPi and DDR

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Learning Objectives

We aim to cover the following topics:

1. The rationale for targeting DDR, including PARP inhibition as the proof of concept.
   • The mechanism of action of PARP inhibitors.
   • Role of diagnostics, and how diagnostics ensure appropriate patient selection.
2. Current role of PARP inhibition in clinical practice, including:
   • The efficacy and safety/tolerability profile of PARP inhibitors.
   • The potential benefit of PARP inhibitors in various tumour types.
   • The appropriate patient selection for PARP inhibition.
   • The current indications for PARP inhibition in clinical practice.
3. Anticipate the potential future application of targeting DDR in clinical practice, including
   • The potential combination strategies with PARP inhibitors.
   • The potential future role of targeting DDR in clinical practice, including drugs with a novel mode of action and their potential combination strategies.
   • The potential future indications for targeting DDR and PARP inhibition and the rationale for targeting DDR in these indications.
   • The potential future role of diagnostics in DDR.