Abstract 288P
Background
Adenosquamous lung carcinoma (ASC) is a rare subtype of invasive lung cancer which accounts for up to four percent of overall invasive lung cancer in the United States. The clinical features of ASC have not been fully understood due to limited patient data. Here, we report disparities by ethnicity and income in patients with ASC.
Methods
The overall survival (OS) was obtained from the Surveillance, Epidemiology, and End Results (SEER) Stat Database 17-registry between 2000–2021. Univariate and multivariate logistic regression analyses were used for the patients with non-metastatic adenosquamous lung carcinoma (Stage I, II, and III) without neoadjuvant chemotherapy. The combined SEER staging and the 3rd, 6th, 7th, and 8th edition of American Joint Committee on Cancer (AJCC) staging were used. Patient subgroups were divided into ethnicity (Hispanic, non-hispanic white; NHW, non-hispanic black; NHB, non-hispanic others; NHO), household income (≥$75,000 vs
Results
Overall, 3,771 patients were included in the final analysis. The independent prognostic factors were age of diagnosis, race, stage, differentiation grade, primary surgery, chemotherapy, radiation, income, and marital status. In ethnic subgroups, the Hispanic subgroup showed better OS than in NHB subgroup (HR 1.19, 95% CI, 1.00–1.43). Hispanic and NHW patients did not reveal significant differences in OS. (HR 1.00, 95% CI, 0.87–1.16). In geographic subgroups, patients in the metropolitan areas did not show significant difference in OS compared to patients in nonmetropolitan areas (HR 0.92, 95% CI, 0.83–1.01). In income subgroups, patients with household income ≥$75,000 revealed better OS than those who have income less than $75,000 (HR 0.82, 95% CI, 0.76–0.88).
Conclusions
Overall, mortality and OS varied among different ethnic groups and regions, though additional studies are warranted for Native Americans or Alaskans with a larger patient dataset. In regards to primary prevention, an early intervention could be especially beneficial for patients in low income. Furthermore, several possible confounding factors such as alcohol or smoking could be further controlled.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.