Abstract 181P
Background
Lung cancer is the leading cause of cancer-related deaths worldwide. Probe-based onfocal laser endomicroscopy (pCLE) is a high-resolution technique that visualizes individual suspected cells in real time and has demonstrated remarkable efficacy in the field of gastroenterology. pCLE facilitates rapid diagnosis through biopsy and aids in the assessment of neoplasms, including the analysis of lung nodules. However, there is currently no comprehensive reviewanalyzing its effectiveness in the respiratory tract and lung fields. This review aims to evaluate the effectiveness of pCLE in diagnosing lung nodules and to explore its potential applications in the respiratory tract.
Methods
A systematic review and meta-analysis were conducted using databases including PubMed, ClinicalKey, Scopus, Nature, ProQuest, and Cochrane. The study was adhered to the PICO framework and PRISMA guidelines, incorporating a 95% confidence interval (CI). The risk of bias for the included studies was assessed using the Cochrane RoB 2.0 tool. Meta-analysis calculations and accuracy of the random-effects model were performed using RevMan 5.4.1.
Results
pCLE achieved a pooled diagnostic sensitivity of 85% (95% CI: 80–90) and specificity of 90% (95% CI: 85–95) for lung nodule malignancy detection. The pooled efficacy for accurate diagnosis was found to be 87% (95% CI: 82–92), with a p-value of
Conclusions
pCLE demonstrates significant promise as a reliable and efficient tool for real-time diagnosis of lung nodules. Its ability to provide immediate visualization and assessment enhances diagnostic accuracy, offering potential for improved patient management in respiratory care.
Legal entity responsible for the study
N.G. Nurisma.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.