Abstract 293P
Background
Despite Cardiovascular diseases (CVD) being a leading global health burden and linked to increased lung cancer risk and poor survival, evidence on their combined mortality is limited. This study aims to quantify the mortality burden of CVD and lung cancer across diverse populations.
Methods
Using data from the CDCWONDER database,we calculated the crude and age-adjusted mortality rates (AAMRs) per 1,000,000 individuals (≥25 years) and used Joinpoint regression to determine annual and average annual percent change (AAPC) in the mortality trends.
Results
A total of 928,780 deaths occurred in the CVD patients with Lung Cancer in the US from 1999–2020, with an overall AAMR of 193.89 (AAPC=−1.53). Men had a significantly higher AAMR than women. Non-Hispanic (NH) Blacks had the highest AAMR, while Hispanics had the lowest. Significant regional variations were observed with highest mortality in the Northeast region. Non-metropolitan areas had a higher AAMR than metropolitan areas. The states with the highest AAMR were Mississippi (300.32) and New York (286.16), while the states with the lowest AAMR were Utah (60.58) and New Mexico (108.2).
Table 293PDeaths and age-adjusted mortality rates (AAMRs) per 1,000,000 for cardiovascular burden and lung cancer among adults in the United States between 1999 and 2020
| Variable | Deaths (n) | AAMR (95% C1) |
| Overall | 928,780 | 193.89 (193.49 to 194.29) |
| SEX | ||
| Female | 392,062 | 144.74 (144.29 to 145.2) |
| Male | 536,718 | 260.34 (259.63 to 261.04) |
| RACE/ETHNICITY | ||
| NH American Indians | 4,029 | 155.9 (150.85 to 160.95) |
| NH Asians | 21,756 | 121.15 (119.51 to 122.8) |
| NH Blacks | 102,298 | 229.47 (228.03 to 230.91) |
| NH White | 764,201 | 201.82 (201.36 to 202.27) |
| Hispanics | 34,308 | 98.94 (97.86 to 100.02) |
| CENSUS REGION | ||
| Northeast | 205,619 | 220.96 (220 to 221.92) |
| Midwest | 195,965 | 182.81 (182 to 183.62) |
| South | 338,832 | 191.87 (191.22 to 192.52) |
| West | 188,364 | 184.58 (183.74 to 185.41) |
| URBANIZATION | ||
| Metropolitan | 740,734 | 188.23 (187.81 to 188.74) |
| Non-metropolitan | 188,046 | 22.18 (22.08 to 22.28) |
Conclusions
Adults in the US have shown a decreasing trend in CVD-related death in patients with Lung cancer. Our study highlights the need for early preventive evaluation and screening for lung malignancies in CVD patients.
Legal entity responsible for the study
M.M. Anjanappa.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.