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Poster Display session

208P - Lung cancer: Precise prediction

Date

31 Mar 2023

Session

Poster Display session

Presenters

Oleg Kshivets

Citation

Journal of Thoracic Oncology (2023) 18 (4S): S149-S153.
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Authors

O. Kshivets

Author affiliations

  • Roshal/RU

Resources

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Abstract 208P

Background

5-survival (5YS) and life span after radical surgery for non-small cell lung cancer (LC) pa­tients (LCP) (T1-4N0-2M0) was analyzed.

Methods

We analyzed data of 771 consecutive LCP (age = 57.6 ± 8.3 years) radically operated and monitored in 1985–2022 (m = 662, f = 109; lobectomies = 516, pneumonectomies = 255; combined procedures = 194; only surgery-S = 620, adjuvant chemoimmunoradiotherapy-AT = 151: CAV/gemcitabine+cisplatin+thymalin/taktivin+radiotherapy 45–50 Gy; T1 = 322, T2 = 255, T3 = 133, T4 = 61; N0 = 518, N1 = 131, N2 = 122, M0 = 771; squamous = 418, adenocarcinoma = 303, large cell = 50; early LC = 215, invasive LC = 556. Variables selected for study were input levels of 45 blood parameters, sex, age, TNMG, cell type, tumor size. Regression, clustering, SEPATH, Monte Carlo, bootstrap, neural networks were used to determine significant dependence.

Results

Overall life span (LS) was 2240.9 ± 1748.8 days and 5-year survival (5YS) reached 73%, 10 years – 64.2%, 20 years – 43%. 503 LCP lived more than 5 years (LS = 3126.6 ± 1536 days), 145 LCP – more than 10 years (LS = 5068.5 ± 1513.2 days).199 LCP died because of LC (LS = 562.7 ± 374.5 days). 5YS of LCP after lobectomies was significantly superior in comparison with LCP after pneumonectomies (77.7% vs. 63.4%, P = 0.00001). AT significantly improved 5YS (64.4% vs. 34.8%) (P = 0.00003 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P = 0.000–0.035). Neural networks, bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank = 1), PT N0–N12 (rank = 2), thrombocytes/CC, eosinophils/CC, erythrocytes/CC, healthy cells/CC, segmented neutrophils/CC, lymphocytes, stick neutrophils/CC, monocytes/CC; leucocytes/CC. Correct prediction of 5YS was 100% by neural networks computing.

Conclusions

5YS of LCP after radical procedures significantly depended on: PT early-invasive cancer; PT N0--N12; cell ratio factors; blood cell circuit; biochemical factors; hemostasis system; AT; LC characteristics; surgery type; LC cell dynamics; anthropometric data.

Legal entity responsible for the study

O. Kshivets.

Funding

Has not received any funding.

Disclosure

The author has declared no conflicts of interest.

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