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Poster Display session

209P - Clinicopathological features and survival outcome of keratinizing versus non-keratinizing squamous cell lung cancer


31 Mar 2023


Poster Display session


Asmaa Ellaithy


Journal of Thoracic Oncology (2023) 18 (4S): S149-S153.


A. Ellaithy

Author affiliations

  • Ismailia/EG


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Abstract 209P


Non-small cell lung cancer represents 85% of all lung cancers. Recently, the histologic subtypes play critical role in patient management and gained importance because of the therapeutic implications of each subtype. Squamous cell subtype accounts for 25% of non-small cell lung cancer with poor prognosis compared to adenocarcinoma. This study aims to assess the impact of keratinization of squamous cell lung cancer on survival outcome with further stratification of the age, grade and stage to fill a gap in the current literature for this subtype.


We obtained the data of 12 229 patients from Surveillance, Epidemiology and End Results (SEER) software, all of them had pathologically confirmed squamous cell lung cancer; keratinizing (n = 8387) and non-keratinizing (n = 3842). They were diagnosed from 2000 to 2019. We used SPSS 23 IBM for data analysis. Kaplan-Meier curve, Log-rank test for survival analysis.


The age standardized 3-year and 5-year survival for squamous cell lung cancer was 30.7% and 22.8% while the 5-year overall relative survival for keratinizing and non-keratinizing squamous cell lung cancer was 21.1% and 28.6%; P > 0.0001. Non-keratinizing type had improved survival outcome in both age groups: 65+ years and less than 65 years (27.9% and 30.0%; P > 0.0001). Performing COX-regression model revealed age, gender, stage and grade were associated with poor survival outcome (P > 0.05).


The non-keratinizing type had slight improved overall survival outcome and survival benefit across all age groups, localized stage, grade I and grade II compared to the keratinizing type. We encourage more studies to evaluate treatment regimens specific to squamous cell lung cancer putting keratinization feature into consideration in addition to the other risk factors.

Legal entity responsible for the study

The author.


Has not received any funding.


The author has declared no conflicts of interest.

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