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Mini Oral session 1

131MO - Trends in age- and sex-specific lung cancer mortality in Europe and Northern America: analysis of vital registration data from the WHO Mortality Database between 2000 and 2017

Date

31 Mar 2022

Session

Mini Oral session 1

Topics

Tumour Site

Non-Small Cell Lung Cancer

Presenters

Philip Baum

Citation

Annals of Oncology (2022) 33 (suppl_2): S93-S96. 10.1016/annonc/annonc863

Authors

P. Baum1, H. Winter2, M. Eichhorn3, J. Lenzi4

Author affiliations

  • 1 Thoraxklinik Heidelberg GmbH, Heidelberg/DE
  • 2 Thoraxklinik Heidelberg gGmbH, 69126 - Heidelberg/DE
  • 3 Thoraxklinik Heidelberg, Heidelberg/DE
  • 4 University of Bologna, Bologna/IT

Resources

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Abstract 131MO

Background

Current comprehensive lung cancer mortality in Europe and Northern America in relation to the new molecular therapy and screening advances is unknown.

Methods

We analysed vital registration data from the WHO Mortality Database (2000-17) covering Northern America and Eastern/Northern/Southern/Western Europe. To assess temporal trends in lung cancer mortality we performed a population-averaged Poisson autoregressive analysis. The average annual percent change (AAPC) calculated with a segmented regression was used as a summary measure of overall and country-specific trends in lung cancer mortality.

Results

In the total population of 872·5 million people between 2015 and 2017, the average annual age-standardised mortality was 54·6 deaths per 100 000 with substantial differences across countries. Lung cancer was reported as the primary cause of death in 5·4 cases per 100 deaths. Age-standardised lung cancer mortality rate decreased constantly (AAPC –1·5%) from 2000 to 2017. Whilst male mortality dropped annually by an average of –2·3%, female mortality only decreased by an average of –0·3%, and this slight decline was driven exclusively by the United States. Conversely, 21 out of 31 countries registered a significant increase in female lung cancer mortality between 2000 and 2017, with Spain (AAPC 4·1%) and France (AAPC 3·6%) leading the list.

Conclusions

Despite the overall decreasing lung cancer mortality trends in Europe and Northern America, in all countries except the US female mortality remained either unchanged or increased. National mortality outcomes are very heterogenous and probably limited from variabilities in tobacco control, screening, and access of effective treatment.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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