Abstract 101P
Background
The aim of our research was to investigate clinicopathological features and degree of malignancy of ground-glass opacity lung cancer associated with cystic airspace (GGO-LCCA), compared with ground-glass opacity lung cancer without cystic airspace (GGO-nLCCA).
Methods
156 patients with GGO-LCCAs were reviewed, focusing on clinical features, histological invasiveness, mutant-gene distribution, and morphological modification on computed tomographic (CT) images. As a control group, 770 patients with GGO-nLCCAs were included. Mutations were examined by targeted next-generation sequencing (NGS). Statistical analysis consisted of Chi-square and Mann-Whitney test.
Results
In the group with GGO-LCCAs, male patients, patients with smoking history, patients with chronic lung disease, patients with pulmonary bullae, and patients with family history of cancer were 75.0% (117/156), 42.3% (66/156), 26.3% (41/156), 34.6% (54/156) and 10.9% (17/156). GGO-LCCAs with lobulated margin, with spiculated margin, with pleural retraction, and with vascular penetration were 12.8% (20/156), 12.8% (20/156), 22.4% (35/156), and 28.2% (44/156). In the analysis of pathology, more lesions of GGO-LCCA were diagnosed as invasive adenocarcinoma (IAC) than GGO-nLCCA (78.8% vs 39.2%, P<0.001). What’s more, micropapillary were observed more frequently in IAC of GGO-LCCAs rather than GGO-nLCCAs (20.7% vs 6.5%, P=0.070). Besides, KRAS (7/49, 14.3% vs 0, P=0.057) mutated more frequently in GGO-LCCAs than in GGO-nLCCAs. Among patients followed up by CT scans, more lesions of GGO-LCCA grew than GGO-nLCCAs (36.7% vs 11.8%, P<0.001). And the group of GGO-LCCA had a shorter median time between baseline and GGO growth, compared with GGO-nLCCA (16.0 months vs 67.0 months, P<0.001).
Conclusions
Patients with GGO-LCCAs had distinct clinical and radiological features. KRAS mutation was more common in GGO-LCCAs. Pathological examination and follow-up CT scans consistently show that GGO-LCCAs are associated with higher aggressiveness.
Legal entity responsible for the study
the First Affiliated Hospital of Guangzhou Medical University.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.