Abstract 98P
Background
For recent years an increasing female to male incidence ratio for lung cancer is observed. Only about 20-25 % of patients are diagnosed at a stage of disease when surgical treatment can be offered. This also concerns women. The results of our and other studies showed that women have better survival after surgical treatment of lung cancer compared with men. The aim of the study was to determine clinical characteristics of a group of young women suffering from lung cancer who had undergone surgical treatment.
Methods
The demographic and clinical data of patients collected retrospectively from a database of the Polish Lung Cancer Study Group (PLCSG) were analysed. Women with NSCLC who were under 55 years old (with complete data in the database) and surgically treated between 2007 and 2020 were included in the study.
Results
1574 women were included, representing 10% of all patients in database. Median age was 52 years (from 22 to 55.0). Based on TNM classification, clinical stage IB was the most common (22.8%) followed by IIIA (19.3%) and IIB (17.7%). 64.0% of young female patients had tobacco smoking history. Adenocarcinoma was the most common histology result (74.3%) followed by squamous cell carcinoma (25.7%). Arterial hypertension (24.1%) and COPD (14.6%) were the most frequently observed comorbidities. Upper lobectomy was the most often performed operation (910, 57.8%), followed by lower lobectomy (453, 28.8%) and (211, 13.4%). The dominant surgical approach was thoracotomy (84.3%). Pneumonectomy was performed in 13% of female patients.
Conclusions
Lung cancer in women, including young women, requires attention. Tobacco smoking remains a serious problem in this group, with COPD as a common comorbidity. The most common TNM stage was IB which proves the early stage of diagnosis. Adenocarcinoma was the most common histopathological type of NSCLC qualifying for surgical treatment among young women, despite significant exposure to smoking.
Legal entity responsible for the study
Polish Lung Cancer Study Group.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.