Abstract 456P
Background
Metastatic colorectal cancer (mCRC) is a major cause of death of malignant tumor and the valuable prognostic biomarker for chemotherapy is crucial in decreasing mortality. IL-10 has been reported decreased after surgery and increased when tumor recurred in operable CRC. However, the prognostic impact of IL-10 in mCRC is still unclear. In this study, we aimed to clarify the prognostic role of IL-10 in mCRC undergoing standard first-line chemotherapy.
Methods
The retrospective study recruited 264 mCRC patients between January 2012 to December 2016 (NCT03532711). All the enrolled patients received oxaliplatin-containing or irinotecan-containing regimen. The expression level of IL-10 in 232 patients’ serum and 68 patients’ tumor tissue was examined. The relationships between IL-10 and clinicopathological characteristics were analyzed. Kaplan- Meier method and Cox regression were used to evaluate the prognostic impact of IL-10.
Results
The median concentration of IL-10 was 7.60 pg/mL before treatment and 11.08 pg/mL after treatment, which suggested that IL-10 level was significantly increased by treatment with chemotherapeutic regimen (p = 0.000). By utilizing univariate and multivariate Cox proportional hazard analyses, we found that low IL-10 level in serum was significantly associated with better overall survival (OS) of mCRC patients treated with irinotecan-containing regimen, with optimal cutoff values of 5.525pg/mL, respectively (p =0.002). In addition, low IL-10 expression level in tumor tissue was significantly associated with better OS for irinotecan-containing regimen (p = 0.023).
Conclusions
Our study demonstrated that IL-10 could act as a prognostic biomarker for mCRC patients undergoing irinotecan-containing chemotherapy.
Clinical trial identification
NCT03532711 (retrospectively registered: May 20th, 2018).
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.