Abstract 1435P
Background
Early-stage gastric signet ring cell carcinoma (SRC) is a candidate of endoscopic treatment. However, there were few population-based data on lymph node metastasis and distant metastasis of gastric SRC. The aim of this study was to identify the risk of lymph node metastasis and distant metastasis in mucosal cancer, very early-stage, suitable for endoscopic treatment.
Methods
Collaborative Stage Data Survey was performed by the Korean Center of Cancer Registry to establish Collaborative Stage Data (CSD) of stomach, colon, rectum, rectosigmoid junction, and breast between 2010 and 2015. In our study, from CSD, patients with gastric SRC were extracted for analysis. Variables included age, sex, diagnosis date, primary site, tumor size, histology, American Joint Committee on Cancer (AJCC) staging system, and Surveillance, Epidemiology, and End Results (SEER) summary stage. These variables were analyzed.
Results
Between 2010 and 2015, 1,335 (65.7%) patients had T1a of gastric SRC. Of them, 1,283 patients (96.1%) had no regional lymph node metastasis (LNM), but 52 (3.9%) had regional LNM. In T1a gastric SRC, 6 (0.4%) patients had distant metastasis. Estimated survival time were higher in negative distant metastasis than positive distant metastasis (8.90 vs 4.66, P<0.0001).
Conclusions
T1a gastric SRC have lymph node and distant metastasis, which are associated with shorter survival time. These findings suggest that before endoscopic treatment, vigorous examination to find lymph node metastasis and distant metastasis should be necessary for safe endoscopic treatment.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
The Korean College of Helicobacter and Upper Gastrointestinal Research Foundation.
Disclosure
The author has declared no conflicts of interest.