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Mini Oral - Head & neck cancer

914MO - Standard versus fractionated high dose cisplatin concomitant with radiotherapy in locally advanced head & neck squamous cell cancer (LA-HNSCC): Results of the GORTEC 2015-02 CisFRad randomized trial


18 Sep 2020


Mini Oral - Head & neck cancer


Tumour Site

Head and Neck Cancers


Christian Borel


Annals of Oncology (2020) 31 (suppl_4): S599-S628. 10.1016/annonc/annonc277


C. Borel1, X. Sun2, A. Coutte3, G. Bera4, S. Zanetta5, M. Alfonsi6, G. Janoray7, T. Chatellier8, M. Garcia-Ramirez9, E. Gherga2, Y. Hammoud10, N. Etienne-Selloum11, A. Pechery12, M. Girard-Calais12, M. Velten13, J. Pignon14, M. Wanneveich12, J. Bourhis15

Author affiliations

  • 1 Medical Oncology Department, Institut de Cancérologie Strasbourg Europe, 67200 - Strasbourg/FR
  • 2 Oncology Radiotherapy Department, Hôpital Nord Franche-Comté - HNFC, 25200 - Montbéliard/FR
  • 3 Radiation Oncology, CHU Amiens-Picardie - Site Sud, 80054 - Amiens/FR
  • 4 Oncology Radiotherapy Department, Centre Hospitalier Bretagne Sud, 56322 - LORIENT/FR
  • 5 Medical Oncology Department, Centre Georges-François Leclerc (Dijon), 21000 - Dijon/FR
  • 6 Oncology Radiotherapy Department, Institut Ste Catherine, 84082 - Avignon/FR
  • 7 Oncology Radiotherapy Department, CHRU Tours, 37000 - Tours/FR
  • 8 Medical Oncology Department, Centre d'Oncologie de l'Estuaire, 44606 - Saint-Nazaire/FR
  • 9 Oncology Radiotherapy Department, Hopital Robert Boulin, 33505 - Libourne/FR
  • 10 Oncology Radiotherapy Department, CHU Besançon, 25000 - Besançon/FR
  • 11 Pharmacie, Institut de Cancérologie Strasbourg Europe, 67200 - Strasbourg/FR
  • 12 Gortec, GORTEC-CHU Bretonneau, 37044 - Tours cedex /FR
  • 13 Biostatistics Department, Institut de Cancérologie Strasbourg Europe, 67200 - Strasbourg/FR
  • 14 Biostatistics Department, Gustave Roussy - Cancer Campus, 94805 - Villejuif/FR
  • 15 Radiation Oncology, CHUV - Centre Hospitalier Universitaire Vaudois, 1011 - Lausanne/CH


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Abstract 914MO


Chemo-radiation (CRT) with high dose cisplatin (Cis) 100 mg/m2 q3w (3 cycles) is the standard of care (SOC) in LA-HNSCC. Cumulative delivered dose of Cis is prognostic of survival, even beyond 200 mg/m2 (P Strojan 2016) but high toxicity compromises its delivery. Fractionated dose of Cis allows decreasing the serum concentration peak and toxicity. No direct comparison was done of SOC vs. fractionated high dose Cis (FHD Cis) leading the GORTEC to conduct a randomized phase II.


The trial, stratified on postoperative or definitive CRT, compares SOC to FHD Cis (25 mg/m2/d d1-4 q3w (3 cycles)) concomitantly to definitive (70 Gy/7 weeks) or postoperative (66 Gy/6.5 weeks) RT. The primary endpoint was the cumulative delivered Cis dose.


A total of 124 patients (pts) were randomized at 10 sites in France: 65 in SOC arm and 59 in FHD Cis arm. Median age: 60, Male: 85%, ECOG 0: 50%, Stage IV: 77%, definitive CRT: 58%, oropharynx: 51% (p16+: 43%), smoking history 89% of pts (median of 40 pack-years), all well balanced between the 2 arms. The median cumulative Cis dose was 291 mg/m2 (interquartile [IQ]: 256-298) for FHD Cis vs. 280 mg/m2 (IQ: 199-295) for SOC (p=0.03). 84% of pts with FHD Cis received the third cycle of Cis vs. 67% with SOC (p=0.03). Overall, 50 (35%) grade III-IV acute toxicities occurred with FHD Cis vs. 91 (65%) with SOC (p<0.001) leading to 19 SAEs with FHD Cis vs. 32 with SOC, including one toxic death with pneumonitis and febrile neutropenia (p=0.07). With a median follow-up of 2.2 years (yrs) (0-3.4), the 2-yr loco-regional failure-free survival (LRFFS) was 61% with FHD Cis vs. 58% with SOC (hazard ratio [HR]=0.97, 95%CI: 0.54-1.74, p=0.91). The 2-yr progression-free and overall survival FHD Cis / SOC were: 54%/ 54% (HR=1.05, 95%CI: 0.60-1.81, p=0.87) and 69%/ 68% (HR=0.88, 95%CI: 0.48-1.66, p=0.67) respectively.


FHD Cis allowed significantly more Cis to be delivered, with significantly lower toxicity, when compared to SOC. LRFFS, PFS and OS were not significantly different between the two arms. FHD Cis concomitantly with RT is a treatment option which deserves further consideration.

Clinical trial identification

EudraCT: 2015-001928-29.

Editorial acknowledgement

Legal entity responsible for the study





C. Borel: Honoraria (self), Advisory/Consultancy, Travel/Accommodation/Expenses: Merck; Honoraria (self), Advisory/Consultancy: BMS; Honoraria (self), Advisory/Consultancy, Travel/Accommodation/Expenses: AstraZeneca; Honoraria (self): MSD. X. Sun: Honoraria (self), Travel/Accommodation/Expenses: Novartis; Honoraria (self): Merck; Advisory/Consultancy: BMS. A. Coutte: Honoraria (self): Merck; Honoraria (self): Takeda; Honoraria (self): BMS; Honoraria (self): Roche; Honoraria (self): Sanofi. G. Bera: Advisory/Consultancy, Travel/Accommodation/Expenses: Sanofi; Advisory/Consultancy, Travel/Accommodation/Expenses: Astellas; Advisory/Consultancy, Travel/Accommodation/Expenses: Janssen; Advisory/Consultancy, Travel/Accommodation/Expenses: BMS. S. Zanetta: Travel/Accommodation/Expenses: Ipsen. M. Alfonsi: Honoraria (self), Advisory/Consultancy: Merck; Honoraria (self), Advisory/Consultancy: Novartis; Advisory/Consultancy: BMS; Advisory/Consultancy: EMD Serono. G. Janoray: Advisory/Consultancy: BMS. T. Chatellier: Advisory/Consultancy, Travel/Accommodation/Expenses: Roche; Advisory/Consultancy, Travel/Accommodation/Expenses: BMS. N. Etienne-Selloum: Honoraria (self): Lilly. J. Bourhis: Advisory/Consultancy: Merck; Advisory/Consultancy: MSD; Advisory/Consultancy: AstraZeneca; Advisory/Consultancy: BMS. All other authors have declared no conflicts of interest.

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