Abstract 122P
Background
The PD-1/PDL-1 system is one of the most notable breakthroughs in understanding the nature of cancer in recent years. The 2018 Nobel Prize was followed by a flurry of research. Expression of PD-L1 is often observed in human cancer. Serum level is an easy way to evaluate the immune regulation of tumor growth. But how useful is it for colorectal cancer?
Methods
The Control Group: 97 people Me(Q1;Q3), aged 58 (45;67), conditionally healthy individuals according to the medical examination. The experimental group including 309 patients aged 66(60;72) were diagnosed with colorectal cancer (adenocarcinoma). For the study, we used the the XMap technology, kit PD-L1 Human ProcartaPlex Kit.
Results
In a study of the general group with colorectal cancer, the PDL-1 marker was found to be 31.12 (0.0; 42.5) pg/ml vs. 10.07 (3.0; 32.5) pg/ml in the control group (p=0.03). The sensitivity was 78.8%, but the specificity was 37% (cut-off of 6.9 pg/ml). At the same time, after surgical treatment (after 1 week), it fell catastrophically to 5.96 (3,1;9.7) pg/ml (p=0.00). Studying the level of PDL1 on the different stage of the cancer, it was found that PDL-1 has not an explicit link with stage (I -32.38(0.0; 40.9) pg/ml; II - 31.37(0.0;44.5) pg/ml; III -29.9(0.0;37.4)pg/ml, IV- 38.45(0.0;44.5)pg/ml). Control vs. I, II, II, IV stage p=0,08; 0,016; 0,032; 0,048. PDL1 level depending on the degree of adenocarcinoma differentiation shows the size of the groups does not allow reaching significance with G1 30,36(1,4; 38,46)pg/ml, however, while G2 33,14 (3,5; 44,0)pg/ml vs. Control p = 0.00; G3 35,42(20,9; 46,39)pg/ml vs. control p = 0.00.
Conclusions
Even though this indicator is highly variable, Serum PD-L1 has shown itself to be a promising marker for tumor growth.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Karaganda Medical University.
Funding
STP O.0821 “Personified approach to the management of a number of significant diseases” funded by the Ministry of Education and Science of the Republic of Kazakhstan.
Disclosure
All authors have declared no conflicts of interest.