Abstract 1870P
Background
Cancer-treatment related Fatigue is a frequent and distressing consequence of anticancer treatment. Multimodal interventions are required (see ESMO CPGL 2020), however, little is known about the effects of structured inpatient cancer rehabilitation programs including both physical and emotional-social components.
Methods
Prospective data collection of inpatients of an integrated cancer rehabilitation service including weekly assessments for goal-directed rehabilitation interventions, steered by a transprofessional rehabilitation team. Rehab-Intervention includes: endurance training incl. water-therapy, proteinrich nutrition, invisible disability directed psychooncolocigal, art and music therapy, mind-body interventions, cognitive-behavioural training to cope with energy levels, social support for back to work and meaning-centered group therapy. Definition of endurance-training responders and non-responders based on five-time-sit-to-stand test. Testing the hypothesis that endurance-training non-responders profit from rehab in the psycho-social domains. Descriptive statistics and t-tests.
Results
Fifty-six patients (54y [31-88], 42 female, BMI 27 [median; 16, 42]; breast (29), lung (4), GI (7), GU (5), HemOnc (9), or other (1) cancer) had chemo/immuntherapy 387 (0, 3678) days before rehab. LOS 29 days (0, 53). Co-factors: CINP 22 (8 >= G2), depression/psychiatric comorbidity (39), endocrine (11) or chronic pain (26). FTSTS: 9.1 sec (4.8; 30), Hand-Grip-Strength 25 / 23 kg, 6 min walking-test 493 meters (58, 661). Brief-Fatigue Inventory 45/90 (0, 74), Fatigue 7/10 (0, 10), cognitive 5, emotional 4, physical 7; QoL 5 (0, 10). HADS-A 7/21 (0, 18), HADS-D 8/21 (0, 18). After Rehab: FTSTS 6.1 (-36%), 6MWT 568, HADS-A 4.5, HADS-D 5; BFI 25, Fatigue 4, cogn 3, emot 1, phys 3. All physical and psychological outcomes improved clinically meaningful in "fit” (non-responding by FTSTS) and unfit patients.
Conclusions
Cancer-treatment related fatigue syndrome rehabilitation is both effective in endurance training responders and non-responders fpr psychological and social outcomes. Further research is justified testing different types of interventions tailored to subgroups.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.