Abstract 676P
Background
Poor baseline nutritional status (NS) is associated with worse HRQoL in patients with metastatic castrate-resistant prostate cancer (mCRPC). Here, we hypothesized that baseline NS remains prognostic for HRQoL six months later.
Methods
We prospectively enrolled men with early mCRPC who started systemic therapy for mCRPC. Based on established criteria, four NS categories were defined: normal NS (nNS), nutritional risk without cachexia/sarcopenia (NR), sarcopenia (S) (handgrip strength <30 kg) and cachexia (C) (Evans`s criteria). HRQoL after six months was measured by the validated questionnaire Functional Assessment of Cancer Treatment (FACT-P). To overcome the problem of dropping out of patients, a sensitivity analysis was performed. Based on a cutoff of 75% total score of FACT-P, patients were categorized into two groups (either good or poor HRQoL). Patients who dropped out because of the disease-related reason were allocated into the poor HRQoL group, while those without known reason of dropping out either into good (conservative case scenario) or poor (liberal case scenario) HRQoL group. Association between NS and HRQoL and was sought in the model of logistic regression.
Results
One hundred forty-one patients were enrolled in our study. At presentation, their mean age was 74.1 years (SD 7.3). Of these 87 (61.7%) and 27 (19.1%) were started on modern hormonal therapy and chemotherapy, respectively. After six months 47 (33.3%) patients dropped out. We found a significant negative prognostic value of NR and cachexia for HRQoL at six months in both case scenarios (for conservative case scenario OR was 0.29 and 0.22; with 95% CI [0.11 to 0.81] and [0.07 to 0.74], respectively). Prognostic value of sarcopenia was non-significant in both case scenarios.
Conclusions
Poor NS has a durable unfavorable impact on HRQoL in men with mCRPC. Early nutritional support is warranted in these patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Bostjan Seruga.
Funding
Slovenian Research Agency.
Disclosure
All authors have declared no conflicts of interest.