Abstract 255P
Background
Patients with breast cancer achieving a pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) have a favourable outcome. However some patients may relapse. Identifying subgroups that have a potential risk of recurrence in this context is essential. The purpose of this study was to identify predictive factors for distant recurrence disease.
Methods
Patients with operable or locally advanced breast cancers treated with NACT in a single institution. pCR was defined as absence of residual invasive cancer in the primary tumour and axillary lymph nodes at surgery. Kaplan-Meier method was used for estimating the DDFS curves, the log rank test was performed to compare the curves and Cox’s proportional hazards model was used to assess the effect of potencial predictive factors for distant disease free survival (DDFS).
Results
537 patients with breast cancer received NACT from 1998 to 2018. Median follow-up was 64,5 months. 119 achieved a pCR (22,2%). Of them, 11 (9,2%) presented an event of interest for DDFS analyses. Five-year DDFS was 91,6%. Predictors for DDFS in univariate analysis were cT stage (χ2=45.408, p<0.001), AJCC Anatomic Stage Groups (χ2= 110,784, p<0.001), and AJCC Clinical Prognostic Stage Groups (χ2= 22,868, p=0.001). In the multivariate analyse only AJCC anatomic stage groups retained significative results for DDFS (p<0,001).
Conclusions
In our study, after pCR in breast cancer patients treated with NACT, only AJCC anatomic stage groups was significant for DDFS in the multivariate analyse. In this special population, these results emphasize the importance of meticulous staging at diagnosis and suggest the possibility of personalised follow-up and modulated adjuvant treatment after surgery based on AJCC anatomic stage groups.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.