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E-Poster Display

1855P - Music therapy can reduce both anxiety and chemotherapy-related nausea and vomiting in patients with early stage colorectal cancer treated with adjuvant infusion chemotherapy: A controlled, randomized study (PEGASUS study)

Date

17 Sep 2020

Session

E-Poster Display

Topics

Supportive Care and Symptom Management

Tumour Site

Colon and Rectal Cancer

Presenters

Ozgur Tanriverdi

Citation

Annals of Oncology (2020) 31 (suppl_4): S988-S1017. 10.1016/annonc/annonc291

Authors

O. Tanriverdi1, T. Karaoglu2, N.F. Aydemir3

Author affiliations

  • 1 Department Of Medical Oncology & Oncological Clinical Researches Centre, Mugla Sitki Kocman University Faculty of Medicine, 48000 - Mugla/TR
  • 2 Student In Semester 6, Mugla Sitki Kocman University Faculty of Medicine, 48000 - Mugla/TR
  • 3 Violent's Teacher & Musicologist, Mugla Art Fine High School, 48000 - Mugla/TR

Resources

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Abstract 1855P

Background

Music therapy is a non-pharmacological approach that can be used in the management of symptoms and side effects in patients with cancer. It is aimed to show the effect of music therapy performed on anxiety and chemotherapy (CT)-related nausea/vomiting in this study.

Methods

A total of 62 patients with stage II and III colon cancer who experienced CT-related nausea and vomiting during the previous cycle and afterwards were randomized to 1: 1. Patients whose music therapy was added to infusion CT were named as the study group (Group 1), and patients who received only infusion CT were named as the control group. Initially, State-trait anxiety inventory (STAI) and Beck depression inventory were filled. Classical music was played to the patients in the study group with a personal headset 3 times a day. After CT was completed, STAI and other study measurements were repeated. Statistical analysis was done using SPPS v19 program and p value was found <0.05 for statistical significance.

Results

In the evaluation made before and after the chemotherapy was completed in Group 1 patients, it was found that there was a significant decrease in both STAI-1 and STAI-2 scores and music therapy significantly changed their anxiety levels. However, no significant difference was found in study measurements related to anxiety in Group 2 patients. In Group 1 patients with music therapy, there was a significant reduction in the number of patients experiencing both nausea and vomiting during chemotherapy. However, there was no significant change in the incidence of nausea and vomiting in Group 2 patients. Music therapy was found to be an independent factor affecting the decrease in nausea-vomiting degree and anxiety (OR 2.98 (1.11-4.07), p=0.029).

Conclusions

It was concluded that music therapy with classical music integrated into the CT session can reduce the degree of nausea/vomiting and anxiety levels.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Mugla Sitki Kocman University Ethical Boars.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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