Abstract 1906P
Background
Patients underwent solid organ transplantation are considered to be associated with an increased risk of developing cancers. We performed a meta-analysis to determine whether there was an increased risk of lung cancer in solid organ transplant recipients.
Methods
PubMed, Web of Science, EMBASE, Medline were searched. Random-effects model meta-analyses were used to calculate standardized incidence ratios (SIRs) for solid organ transplant recipients versus the general population, stratified by types of transplantation. Subgroup analyses were performed based on country/region of each study.
Results
Based on data from 531,377 patients with a total follow-up of 307,7669 patient-years, we identified a 5.97 -fold higher SIR [95% confidence intervals (CI) 4.66-7.66, P<0.001] in lung transplantation recipients, a 2.61-fold higher SIR of lung cancer [95% CI 2.14-3.17, P=0.012] in patients underwent heart transplantation, a 1.89-fold higher SIR [95% CI: 1.6-2.22, P=0.001] in patients following liver transplantation, and a 1.45-fold higher SIR [95% CI: 1.23-1.7, P<0.001] in renal transplantation recipients, compared with the general population. In subgroup analyses, we found that the order of lung cancer SIR after different transplantation types (lung, heart, liver and kidney) was consistent among different ethnic groups, and European and North American countries had the highest SIRs compared with Asians and Oceania (Table). Table: 1906P
| Transplant type | SIR (95%CI) | P-value |
| Lung transplant (N=18) | 5.97 (4.66-7.66) | <0.001 |
| Europe (N=4) | 8.73 (4.39-17.34) | 0.001 |
| North America (N=3) | 5.67 (4.68-6.87) | 0.038 |
| Heart transplant (N=10) | 2.61 (2.14-3.17) | 0.012 |
| Europe (N=5) | 3.21 (2.24-4.61) | 0.002 |
| North America (N=3) | 1.95 (1.20-3.15) | 0.017 |
| Liver transplant (N=20) | 1.89 (1.60-2.22) | <0.001 |
| Europe (N=11) | 1.82 (1.46-2.28) | <0.001 |
| North America (N=2) | 1.93 (1.72-2.16) | 0.001 |
| Asia (N=4) | 2.66 (1.42-4.99) | <0.001 |
| Oceania (N=3) | 0.48 (0.10-1.42) | 0.064 |
| Kidney transplant (N=20) | 1.45 (1.23-1.70) | <0.001 |
| Europe (N=10) | 1.45 (1.26-1.68) | <0.001 |
| North America (N=5) | 1.18 (0.82-1.68) | 0.065 |
| Asia (N=5) | 2.01 (1.24-3.26) | <0.001 |
Conclusions
Our study demonstrated that solid transplant recipients showed a significantly greater risk of lung cancer, which varied among different transplantation types and ethnic groups. Such association can provide guidance for clinicians in the detection of lung cancer among solid organ transplantation recipients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.