Abstract 1663P
Background
Soft tissue sarcomas (SMT) are a relatively uncommon pathology, accounting for 1.0 to 2.5% of all malignancies in adults. This type of tumour has a poor prognosis and course, and the understanding of this pathology is still low due to the small number of cases. The aim of the study was to determine the impact of local recurrence on overall 5-year survival of patients with STS.
Methods
The 5-year survival rate of 429 patients with primary localized SMT of the extremities and body, which were treated in the National Cancer Institute, Kyiv, Ukraine, in the period from 2000 to 2014, were analysed depending on the presence or absence of local recurrences during the observation period. All patients were divided into 2 groups: group1 consisted of 241 patients who underwent surgical treatment and chemo-radiation treatment and did not have local recurrences during the observation period; group 2 consisted of188 patients who received similar treatment to group 1 at the initial stage, but in this group local recurrences were detected during the observation period which were treated with both surgical and chemoradiation methods.
Results
5-year overall survival in group 1 was 43.1% ± 4.6 and in group 2 it was 43.6% ± 5.9 (P = 0.9). The median survival differed in these groups: in group 1 it was 35 months and in group 2 it was 41 months (HR = 1.13; P = 0.41).
Conclusions
Overall survival did not deteriorate in patients with SMT with local recurrences, but the median survival was slightly higher compared to SMT patients in whom local recurrence was not observed. It can be assumed that the occurrence of local recurrences in patients with SMT does not worsen the prognosis of life expectancy.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.