Abstract 200P
Background
Adjuvant endocrine therapy may cause alterations in serum lipids in postoperative breast cancer (BC) patients, but the specific alterations caused by different endocrine agents remain unclear. The aim of this study was to investigate the status of serum lipids during the 5-year endocrine therapy and to compare the effects of different endocrine drugs on lipid profiles.
Methods
We retrospectively analysed the lipid profiles during the 5-yera treatment of 1487 consecutive postoperative BC patients from February 2009 to December 2016. Lipid parameters include triglycerides (TG), total cholesterols (TC), low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C). The levels of TG, TC, HDL and LDL were measured at baseline and 1, 2, 3, 4 and 5 years following the initiation of endocrine therapy, respectively.
Results
For premenopausal BC patients, LDL levels rapidly decreased at 1 year in the tamoxifene (TAM) group compared with baseline (p<0.05), and the decline remained for the following 4 years. Also, compared with the control group, LDL was significantly lower in TAM group at all the assessment time points (p<0.05). Similarly, TC also decreased in the TAM group compared with baseline (p<0.05) and compared with the control group, TC was also lower for the first 4 years. For postmenopausal BC patients, there was no statistical difference in the lipid profiles (TG, TC, LDL and HDL) in letrozole (LET), anastrozole (ANA) and exemestane (EXE) group compared with the control group, respectively. As for patients received TAM, compared with the control group, TC decreased at 1 year; and LDL decreased at 1 and 2 year.
Conclusions
TAM may improve serum lipids mainly on LDL and TC levels in premenopausal BC patients. While for those postmenopausal, aromatase inhibitors (AI) may have no adverse effects on lipid profiles; and TAM may have little beneficial effects on serum lipid.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
West China School of Medicine/West China Hospital, Sichuan University.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.