Abstract 284P
Background
The growing number of oral therapies indicated for MBC highlights the need of a specific approach in order to improve both compliance and safety of these new drugs. This observation led the François Baclesse Cancer Center to initiate a pathway for initial prescription (chemotherapies and targeted therapies), thanks to a multidisciplinary team with a specific role for each professional. We present here the results of a prospective observational study of the first year of this pathway.
Methods
After indication of an oral therapy for MBC, each patient benefits of 3 consultations (medical oncologist, pharmacist, breast care nurse). During the medical visit, the oncologist is in charge of the treatment prescription and patient’s information about the risk of adverse events (AEs). The role of the pharmacist is both before the medical visit (informs the medical oncologist on possible drug-drug interactions) and after (informs the patient about the personalized treatment calendar, detects potential interactions with herbal medicine or food). The breast care nurse ensures a comprehensive education aiming to help patients to anticipate side effects (for example, what type of AEs can be managed at home and how), and evaluates the need of supportive care. A data collection was conducted during 14 months, from December 2018 to February 2020.
Results
270 patients benefited from this multidisciplinary consultation between December 2018 and February 2020, 193 targeted therapies and 77 chemotherapies were prescribed. In total, 36% of pharmaceutical interventions (PI) were carried out. 46% of PI led to a discontinuation of one of the drugs usually taken by the patient, 19% led to a substitution, 13% to a dosage adjustment. The whole results will be presented at the congress.
Conclusions
The aim of this multidisciplinary consultation is to provide a safe medication management and preserve quality of life of patients. This will help maintaining patient autonomy, increasing adherence and patient satisfaction. Finally, this approach aim to reinforce the link between hospital and ambulatory care by encouraging relations between professionals.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.