Abstract 392P
Background
Global studies have showed varying trends of central nervous system (CNS) tumors within geographical regions. In Colombia, the epidemiological characteristics of CNS neoplasms are not well elucidated. We aimed to describe the incidence, mortality, and survival trends of primary CNS tumors in Cali, Colombia.
Methods
We conducted a population-based study from 1962 to 2019 using the Population-based Cali Cancer Registry (PCCR). The PCCR is the oldest source of descriptive epidemiology data in Latin America, recognized by the IARC. The age-standardized rates (per 100,000 person-year) were obtained by the direct method with the world standard population. Joinpoint regression analysis was used to detect trends and obtain annual percent change (APC) with 95% confidence intervals (95% CI). We estimated 5-year net survival with Pohar Permer.
Results
During 1962-2016, a total of 4,732 new cases of CNS tumors were reported. A total of 2,475 deaths were attributed to malignant CNS neoplasms from 1984-2019. A statistically significant increased incidence (APC=2.8; 95%CI=2.1-3.5) and mortality (APC=1.5; 95%CI=1.1-2.0) rates trend was observed during the study period. The most common malignant CNS tumor was the glioblastoma (17.8% of all tumors), and the most frequent benign tumor was the meningioma (17.2%). In children (0-14 years old), the largest group of CNS tumors was the diffuse astrocytoma (16.6%) followed by medulloblastoma (14.5%). Unspecified malignant neoplasms represented 32% of all cases. The 74.4% of all CNS tumors had microscopic confirmation. The highest 5-year net survival was 31.4% during 2012-2016.
Conclusions
Our findings demonstrate an increasing burden of primary CNS tumors for the last 60 years in Cali, Colombia. Males had higher mortality than females. Survival outcome has improved since the early-2010s.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Population-based Cali Cancer Registry.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.