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E-Poster Display

190P - Impact of chemotherapy for early stage breast cancer on quality of life in older adults: Results from 2811 women enrolled in the Bridging the Age Gap study

Date

17 Sep 2020

Session

E-Poster Display

Presenters

Nicolò Matteo Luca Battisti

Citation

Annals of Oncology (2020) 31 (suppl_4): S303-S339. 10.1016/annonc/annonc267

Authors

N.M.L. Battisti1, E. Herbert2, M. Bradburn2, J. Morgan3, L. Wyld3, A. Ring1

Author affiliations

  • 1 Department Of Medicine - Breast Unit, The Royal Marsden Hospital NHS Foundation Trust, SM2 5PT - Sutton/GB
  • 2 School Of Health And Related Research - Clinical Trials Research Unit, University of Sheffield, S1 4DA - Sheffield/GB
  • 3 Department Of Oncology And Metabolism, University of Sheffield Medical School, S10 2RX - Sheffield/GB
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Resources

Abstract 190P

Background

Older patients with early breast cancer (EBC) are heterogenous and more vulnerable to chemotherapy toxicities, which makes assessing quality of life (QoL) key in the curative setting. However, data on QoL in this age group are limited. We aimed to investigate the impact of chemotherapy on QoL in older EBC patients enrolled in the Bridging the Age Gap study.

Methods

A prospective, multicentre, observational study of women over 70 with EBC was conducted in 2013-2018 at 56 UK Institutions. Demographics, patient and tumour characteristics, treatments, adverse events and QoL were recorded for up to 24 months. QoL was analysed at each time point using baseline adjusted linear regression for high-risk patients.

Results

3416 patients were enrolled and 2811 (82.3%) having surgery were included in the analysis. EBC was N+ in 837 (29.8%), ER+ in 2354 (83.7%) and HER2+ in 332 (11.8%). Patients had median age of 76.5 years (range 69-95). A full comprehensive geriatric assessment was performed at baseline including validated tools. In these 2811 patients, 1520 (54.1%) were high risk and 376 (24.7%) received chemotherapy. Compared with patients not receiving cytotoxics, at 6 months after diagnosis chemotherapy had a significant impact on several EORTC-QLQ-C30 domains, including global health score (61.7 [22.3] versus 69.5 [19.2], p<0.001), fatigue (44.3 [26.2] versus 33.3 [22.7], p<0.001), appetite loss (26.2 [32.6] versus 12.7 [22.7], p<0.001). Physical functioning, role functioning, cognitive functioning, social functioning, nausea, dyspnoea, constipation, diarrhoea and financial problems were also influenced. Similar trends were documented on other scales (EORTC-QLQ-BR23, EORTC-QLQ-ELD15 and EQ-5D-5L). However, differences were no longer significant at 18-24 months.

Conclusions

The impact of chemotherapy use on QoL outcomes in this population is relevant at 6 months and becomes more limited until resolving at 18 months. These are important information to share with older patients contemplating chemotherapy to describe its short- and long-term impact on QoL.

Clinical trial identification

ISRCTN: 46099296.

Editorial acknowledgement

Legal entity responsible for the study

Lynda Wyld.

Funding

National Institute for Health Research (NIHR).

Disclosure

All authors have declared no conflicts of interest.

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