Abstract 42P
Background
Gastric cancer (GC) is one of the most common cancers in the world. The aims of this study were to evaluate the association between a polymorphism rs710886 in long noncoding RNA (lncRNA) prostate cancer-associated transcript 1 (PCAT1) and the risk of GC and GC subgroups via a case-control study.
Methods
Genotyping of rs710886 was conducted by using TaqMan genotyping assay with 460 GC patients and 377 controls.
Results
After adjusted for age and gender, the rs710886 was associated with an increased risk of GC in subjects aged ≥60 years (dominant model: adjusted OR = 1.68, 95% CI = 1.04-2.72, P = 0.035), GC in male subjects (AG: adjusted OR = 2.28, 95% CI = 1.38-3.79, P = 0.001; dominant model: adjusted OR = 1.87, 95% CI = 1.18-2.96, P = 0.008), GC in subjects with well differentiated tumor type (AG: adjusted OR = 1.64, 95% CI = 1.03-2.60, P = 0.037; dominant model: adjusted OR = 1.57, 95% CI = 1.01-2.44, P = 0.046).
Conclusions
Our findings suggest that the rs710886 in lncRNA PCAT1 associated with increased the susceptibility of GC and may exacerbates the development of GC. Further studies are needed to validate our results in large populations as well as different ethnic groups.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
National Research Foundation of Korea.
Disclosure
The author has declared no conflicts of interest.