Abstract 2009P
Background
There are some evidences suggesting the link between BRCA1/2 germ-line mutations and increased risk of gastric cancer.
Methods
We performed endoscopic screening for stomach malignancies in 120 BRCA1 mutation carriers and 110 controls.
Results
No instances of gastric cancer were detected at first visit. The analysis of atrophic changes performed by OLGA (Operative Link for Gastritis Assessment) staging revealed identical frequencies of mucosal abnormalities in carriers vs. non-carriers. BRCA1 mutation carriers demonstrated significant association between gastric atrophy and age: OLGA stages I-IV alterations were observed in 26/41 (63%) subjects aged > 50 years old as compared to 29/79 (37%) in younger subjects (P = 0.007, χ2-test). However, this age-related trend was not observed in the mutation non-carriers. One BRCA1 mutation carrier developed gastric cancer in four years after the first visit to endoscopic examination. We performed next-generation sequencing analysis for this tumour and additional 4 archival gastric cancers obtained from BRCA1/2 mutation carriers. Somatic loss of the remaining BRCA1/2 allele was observed in 3 out of 5 tumours analyzed; all these carcinomas but not the malignancies with the retained BRCA1/2 copy showed chromosomal instability.
Conclusions
Taken together, these data justify further studies on the relationships between the BRCA1/2 and gastric cancer.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
The Russian Foundation for Basic Research [grant number 18-29-09090].
Disclosure
All authors have declared no conflicts of interest.