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E-Poster Display

1041P - Explore the efficacy of immune checkpoint inhibitors in non-small cell lung cancer patients of different gender

Date

17 Sep 2020

Session

E-Poster Display

Presenters

Shu-yue Zheng

Citation

Annals of Oncology (2020) 31 (suppl_4): S645-S671. 10.1016/annonc/annonc279

Authors

S. Zheng1, H. Cui2

Author affiliations

  • 1 Graduate School, Beijing University of Chinese Medicine, 100029 - Beijing/CN
  • 2 Department Of Integrative Oncology, China-Japan Friendship Hospital, 100029 - Beijing/CN
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Resources

Abstract 1041P

Background

Gender associated differences in immune response are common. Latest clinical trials have proved the better overall survival (OS) for the use of immune checkpoint inhibitors (ICIs) verse chemotherapy in non-small cell lung cancer (NSCLC) patients. However, we still have no clear ideas of the efficacy of them in different gender. Therefore, we conducted a meta-analysis to compare the efficacy of ICIs for NSCLC patients of different gender groups and summarized overall treatment-related adverse events.

Methods

PubMed, EMBASE, Web of Science and the Cochrane Library were searched for all clinical trials in NSCLC until 28th of July 2019. Eligible studies included randomized controlled trials (RCTs) comparing ICIs with chemotherapy in NSCLC patients. The hazard ratio (HRs) and 95% confidence intervals (CIs) of OS, progression-free survival (PFS) or adverse events (AEs) were used.

Results

A total of 5199 patients from 8 RCTs were included. ICIs significantly prolonged the OS (HR, 0.75; 95% CI, 0.67–0.84) and PFS (HR, 0.62; 95% CI, 0.47–0.83) versus chemotherapy in male NSCLC patients. Also, they prolonged the OS (HR, 0.62; 95% CI, 0.45–0.87) in female NSCLC patients. However, there was no statistical significance of PFS (HR, 0.64; 95% CI, 0.39–1.04) among female NSCLC patients. It also showed that the single use of ICIs had fewer all-grade AEs compared with the combination of ICIs and chemotherapy.

Conclusions

NSCLC patients could achieve better OS from ICIs than chemotherapy treatment regardless of their gender. But there was no significant difference in the PFS of female NSCLC patients. Male patients might be likely to get better results in the treatment of ICIs which needs to be further investigated.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Capital’s Funds for Health Improvement and Research (No.2018-2-4065), National Natural Science Foundation of China (No. 81873396) and China-Japan Friendship Hospital.

Disclosure

All authors have declared no conflicts of interest.

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